Research output per year
Research output per year
Personal profile
Biography
Dr Dennis Beringer is an assistant professor in the Center for Translational Immunology (CTI) at the University Medical Center Utrecht, the Netherlands. He obtained his PhD at Utrecht University in the field of structural biology. After which he moved to Monash University, Australia, where he investigated the molecular details of T cell receptor (TCR) – antigen interactions in autoimmune diseases and cancer. Intrigued by TCR biology, he returned to Utrecht to join the group of Jürgen Kuball at the UMCU in 2016 to study the molecular determinants of tumor reactive γδTCRs, for which he received a Marie Curie Individual Fellowship. Currently, he and his team are focusing on the optimization of existing and the development of novel γδ-TCR based therapeutics for cancer therapy, with a special emphasis on a new class of bispecific T cell engagers called GABs.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Hernández-López, P., van Diest, E., Brazda, P., Heijhuurs, S., Meringa, A., Hoorens van Heyningen, L., Riillo, C., Schwenzel, C., Zintchenko, M., Johanna, I., Nicolasen, M. J. T., Cleven, A., Kluiver, T. A., Millen, R., Zheng, J., Karaiskaki, F., Straetemans, T., Clevers, H., de Bree, R., Stunnenberg, H. G., & 6 others, Jan 2024, In: Nature immunology. 25, 1, p. 88-101 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies
Meringa, A. D., Hernández-López, P., Cleven, A., de Witte, M., Straetemans, T., Kuball, J., Beringer, D. X. & Sebestyen, Z., 2023, In: Frontiers in Immunology. 14, p. 1-7 1159337.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
Open AccessFile4 Downloads (Pure) -
The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers
van Diest, E., Nicolasen, M. J. T., Kramer, L., Zheng, J., Hernández-López, P., Beringer, D. X. & Kuball, J., 5 Jan 2023, In: Frontiers in Immunology. 13, 1052090.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults
Vyborova, A., Janssen, A., Gatti, L., Karaiskaki, F., Yonika, A., van Dooremalen, S., Sanders, J., Beringer, D. X., Straetemans, T., Sebestyen, Z. & Kuball, J., 7 Jul 2022, In: Frontiers in Immunology. 13, p. 1-13 915366.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Downloads (Pure) -
Adding Help to an HLA-A*24:02 Tumor-Reactive gamma delta TCR Increases Tumor Control
Johanna, I., Hernández-López, P., Heijhuurs, S., Scheper, W., Bongiovanni, L., de Bruin, A., Beringer, D. X., Oostvogels, R., Straetemans, T., Sebestyen, Z. & Kuball, J., 25 Oct 2021, In: Frontiers in Immunology. 12, p. 1-12 752699.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Downloads (Pure)