TY - JOUR
T1 - Reliability and validity of an instrument for the assessment of bradykinesia
AU - Mentzel, Thierry Q.
AU - Lieverse, Ritsaert
AU - Levens, Amar
AU - Mentzel, Charlotte L.
AU - Tenback, Diederik E.
AU - Bakker, P. Rob
AU - Daanen, Hein A.M.
AU - van Harten, Peter N.
PY - 2016/4/30
Y1 - 2016/4/30
N2 - Bradykinesia is associated with reduced quality of life and medication non-compliance, and it may be a prodrome for schizophrenia. Therefore, screening/monitoring for subtle bradykinesia is of clinical and scientific importance. This study investigated the validity and reliability of such an instrument. Included were 70 patients with psychotic disorders. Inertial sensors captured mean cycle duration, amplitude and velocity of four movement tasks: walking, elbow flexion/extension, forearm pronation/supination and leg agility. The concurrent validity with the Unified Parkinson's Disease Rating Scale (UPDRS) bradykinesia subscale was determined using regression analysis. Reliability was investigated with the intra-class correlation coefficient. The duration, amplitude and velocities of the four tasks measured by the instrument explained 67% of the variance on the UPDRS bradykinesia subscale. The instrument test-retest reliability was high. The instrument investigated in this study is a valid and reliable alternative to observer-rated scales. It is an ideal tool for monitoring bradykinesia as it requires little training and experience to achieve reliable results.
AB - Bradykinesia is associated with reduced quality of life and medication non-compliance, and it may be a prodrome for schizophrenia. Therefore, screening/monitoring for subtle bradykinesia is of clinical and scientific importance. This study investigated the validity and reliability of such an instrument. Included were 70 patients with psychotic disorders. Inertial sensors captured mean cycle duration, amplitude and velocity of four movement tasks: walking, elbow flexion/extension, forearm pronation/supination and leg agility. The concurrent validity with the Unified Parkinson's Disease Rating Scale (UPDRS) bradykinesia subscale was determined using regression analysis. Reliability was investigated with the intra-class correlation coefficient. The duration, amplitude and velocities of the four tasks measured by the instrument explained 67% of the variance on the UPDRS bradykinesia subscale. The instrument test-retest reliability was high. The instrument investigated in this study is a valid and reliable alternative to observer-rated scales. It is an ideal tool for monitoring bradykinesia as it requires little training and experience to achieve reliable results.
KW - Antipsychotic-induced
KW - Diagnostic techniques and procedures
KW - Extrapyramidal disorders
KW - Micro-electrical-mechanical systems
KW - Parkinsonism
KW - Reproducibility of findings
KW - Schizophrenia and disorders with psychotic features
UR - https://www.scopus.com/pages/publications/84959019411
U2 - 10.1016/j.psychres.2016.02.011
DO - 10.1016/j.psychres.2016.02.011
M3 - Article
C2 - 27086232
AN - SCOPUS:84959019411
SN - 0165-1781
VL - 238
SP - 189
EP - 195
JO - Psychiatry Research
JF - Psychiatry Research
ER -