Emerging roles of cohesin-STAG2 in cancer

Julia S. Scott; Loubna Al Ayadi; Emmanouela Epeslidou; Roan H. van Scheppingen; Anna Mukha; Lucas J.T. Kaaij; Catrin Lutz; Stefan Prekovic

doi:10.1038/s41388-024-03221-y

Emerging roles of cohesin-STAG2 in cancer

Julia S. Scott
, Loubna Al Ayadi
, Emmanouela Epeslidou
, Roan H. van Scheppingen
, Anna Mukha
, Lucas J.T. Kaaij
, Catrin Lutz
, Stefan Prekovic^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Cohesin, a crucial regulator of genome organisation, plays a fundamental role in maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 stands out because of its frequent deleterious mutations in various cancer types, such as bladder cancer and melanoma. Loss of STAG2 function leads to significant alterations in chromatin structure, disrupts transcriptional regulation, and impairs DNA repair pathways. In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2 dysfunction promotes tumourigenesis and presents opportunities for targeted therapeutic interventions.

Original language	English
Article number	70
Pages (from-to)	277–287
Number of pages	11
Journal	Oncogene
Volume	44
Issue number	5
Early online date	29 Nov 2024
DOIs	https://doi.org/10.1038/s41388-024-03221-y
Publication status	Published - 18 Feb 2025

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10.1038/s41388-024-03221-y

s41388-024-03221-yFinal published version, 1.12 MBLicence: Taverne

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title = "Emerging roles of cohesin-STAG2 in cancer",

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AU - Scott, Julia S.

AU - Al Ayadi, Loubna

AU - Epeslidou, Emmanouela

AU - van Scheppingen, Roan H.

AU - Mukha, Anna

AU - Kaaij, Lucas J.T.

AU - Lutz, Catrin

AU - Prekovic, Stefan

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AB - Cohesin, a crucial regulator of genome organisation, plays a fundamental role in maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 stands out because of its frequent deleterious mutations in various cancer types, such as bladder cancer and melanoma. Loss of STAG2 function leads to significant alterations in chromatin structure, disrupts transcriptional regulation, and impairs DNA repair pathways. In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2 dysfunction promotes tumourigenesis and presents opportunities for targeted therapeutic interventions.

UR - https://www.scopus.com/pages/publications/85210600714

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JO - Oncogene

JF - Oncogene

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M1 - 70

ER -

Emerging roles of cohesin-STAG2 in cancer

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Correction to: Emerging roles of cohesin-STAG2 in cancer (Oncogene, (2025), 44, 5, (277-287), 10.1038/s41388-024-03221-y)

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