Research output per year
Research output per year
Personal profile
Personal webpage
Biography
Wouter de Laat studied biology at the Utrecht University. During his PhD (1998) at the Erasmus University Rotterdam (Prof. Jan Hoeijmakers) he investigated the molecular mechanism of nucleotide excision repair. He identified one of the nucleases and characterized the interplay between repair factors at the site of the lesion. As a postdoc, he joined the group of Prof. Frank Grosveld to work on beta-globin gene activation. In 2000 he received a career grant (VIDI) to work on long-range gene activation. His group used 3C technology, and later developed 4C technology, to demonstrate chromatin loops between genes and enhancers and to uncover long-range DNA contacts within and between chromosomes.
In 2008 he received an ERC Young Investigator Grant. In September 2008 de Laat moved his group to the Hubrecht Institute, where he continued his work on genome structure and function. In January 2009 he was appointed professor in Biomedical Genomics at the University Medical Center Utrecht. He received a prestigious VICI career grant in 2012.
Side activities
- Mentor UAF, Universitair Asielfonds
- Founder of Cergentis. Cergentis was acquired by Solvias in 2022. Wouter de Laat no longer has financial interest/role in Cergentis.
- Scientific Advisory Board Max Planck Institute for Molecular Genetics Berlin
Fellowship & awards
VIDI (2000)
VICI (2012)
ERC Starting Grant (2008)
EMBO Member
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs
Venema, W. J., Hiddingh, S., van Loosdregt, J., Bowes, J., Balliu, B., de Boer, J. H., Ossewaarde-van Norel, J., Thompson, S. D., Langefeld, C. D., de Ligt, A., van der Veken, L. T., Krijger, P. H. L., de Laat, W. & Kuiper, J. J. W., 10 Jan 2024, In: Cell genomics. 4, 1, 100460.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Downloads (Pure) -
CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands
Rouillon, C., Eckhardt, B. V., Kollenstart, L., Gruss, F., Verkennis, A. E. E., Rondeel, I., Krijger, P. H. L., Ricci, G., Biran, A., van Laar, T., Delvaux de Fenffe, C. M., Luppens, G., Albanese, P., Sato, K., Scheltema, R. A., de Laat, W., Knipscheer, P., Dekker, N. H., Groth, A. & Mattiroli, F., 8 May 2023, In: Nucleic acids research. 51, 8, p. 3770-3792 23 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Downloads (Pure) -
Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia
Smits, W. K., Vermeulen, C., Hagelaar, R., Kimura, S., Vroegindeweij, E. M., Buijs-Gladdines, J. G. C. A. M., van de Geer, E., Verstegen, M. J. A. M., Splinter, E., van Reijmersdal, S. V., Buijs, A., Galjart, N., van Eyndhoven, W., van Min, M., Kuiper, R., Kemmeren, P., Mullighan, C. G., de Laat, W. & Meijerink, J. P. P., 25 Apr 2023, In: Cell Reports. 42, 4, 25 p., 112373.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Formalin-Fixed, Paraffin-Embedded-Targeted Locus Capture: A Next-Generation Sequencing Technology for Accurate DNA-Based Gene Fusion Detection in Bone and Soft Tissue Tumors
Stelloo, E., Meijers, R. W. J., Swennenhuis, J. F., Allahyar, A., Hajo, K., Cangiano, M., de Leng, W. W. J., van Helvert, S., Van der Meulen, J., Creytens, D., van Kempen, L. C., Cleton-Jansen, A-M., Bovee, J. V. M. G., de Laat, W., Splinter, E. & Feitsma, H., Oct 2023, In: Journal of Molecular Diagnostics. 25, 10, p. 758-770 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Downloads (Pure) -
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes
Rinzema, N. J., Sofiadis, K., Tjalsma, S. J. D., Verstegen, M. J. A. M., Oz, Y., Valdes-Quezada, C., Felder, A. K., Filipovska, T., van der Elst, S., de Andrade dos Ramos, Z., Han, R., Krijger, P. H. L. & de Laat, W., Jun 2022, In: Nature Structural and Molecular Biology. 29, 6, p. 563-574 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Citations (Scopus)6 Downloads (Pure)