Zijn de risicofactoren voor een coronaire hartziekte leeftijdsafhankelijk?

Translated title of the contribution: Cardiovascular risk factors from an aging perspective

Mike J.L. Peters, Joline W.J. Beulens, Majon Muller

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

There is a clear increase in cardiovascular risk with increasing age. However, in relative terms the contribution of individual cardiovascular risk factors such as BMI or blood pressure to the occurrence of cardiovascular disease weakens with age. Whether these weaker associations are causal or driven by other confounding factors is unclear. If such associations are indeed causal, this would imply that cardiovascular risk factors require less intensive treatment with ageing. A recent study using mendelian randomization techniques confirmed that the causal relationship of cardiovascular risk factors with the occurrence of coronary artery disease weakens with age. In this article we discuss the possible contribution of mendelian randomization studies in studying casual relationships between cardiovascular risk factors and cardiovascular disease. We also comment on what the possible consequences are for cardiovascular risk management in older people in daily clinical practice.

Translated title of the contributionCardiovascular risk factors from an aging perspective
Original languageDutch
Article numberD6829
JournalNederlands Tijdschrift voor Geneeskunde
Volume167
Publication statusPublished - 4 Jan 2023

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