Yttrium-90 radioembolisation for treatment of colorectal cancer liver metastases

CENM Rosenbaum

Research output: ThesisDoctoral thesis 1 (Research UU / Graduation UU)

Abstract

The thesis includes a systematic review on yttrium-90 radioembolisation (Y90-RE) and two chapters on the pre-treatment work-up of eligible patients, i.e. on the added value of FDG-PET imaging and on activity planning.
The main research project consisted of a prospective cohort study in which 42 patients with colorectal cancer liver metastases were enrolled. Prior to and after treatment with Y90-RE, blood samples were collected. Several angiogenic factors were analyzed and a significant increase in plasma values of angiopoietin-2 and hepatocyte growth factor were demonstrated in patients with rapidly progressive disease. This suggests that the concomitant use of anti-angiogenic treatment with Y90-RE may increase response rates.
Within this cohort study, dose-response relationship and quality of life were also investigated. A strong dose-response relationship was demonstrated, and higher doses are required for more metabolically active lesions. Quality of life did not deteriorate significantly and relatively little side effects were reported.
Original languageEnglish
Awarding Institution
  • University Medical Center (UMC) Utrecht
Supervisors/Advisors
  • Lam, Marnix, Primary supervisor
  • Koopman, M, Supervisor
Award date7 Nov 2017
Publisher
Print ISBNs978-94-6332-238-6
Publication statusPublished - 7 Nov 2017

Keywords

  • Radioembolisation
  • Colorectal cancer liver metastases
  • Angiogenesis
  • Quality of life

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