TY - JOUR
T1 - Yield of family screening in patients with isolated bicuspid aortic valve in a general hospital
AU - Cozijnsen, Luc
AU - van der Zaag-Loonen, Hester J
AU - Braam, Richard L.
AU - Boo, Mirjam Bakker de
AU - Post, Jan G.
AU - Bouma, Berto J.
AU - Mulder, Barbara J M
PY - 2018/3/15
Y1 - 2018/3/15
N2 - Aim: To determine the prevalence of unidentified bicuspid aortic valve (BAV) or aortic dilatation (>. 40. mm) in first degree relatives (FDR) of patients with isolated BAV in a general hospital. Methods and results: Patients with isolated BAV received information advising cardiac screening of their FDR. Referred and screened were 134 FDR of 54 adult index patients with isolated BAV (median 2 per index patient). FDR's mean age was 49. years (range 16-83. years) and 41% were male. They comprised 5 parents (3.7%), 52 siblings (39%) and 77 offspring (57%). Among these FDR, the prevalence of BAV was 6.0% (8 patients). In FDR without BAV, 10 (7.5%) had aortic dilatation. 'Familial BAV' was present in 9/54 families (17%). Conclusion: In a general hospital, screening of FDR of patients with isolated BAV resulted in a substantial yield of 13% new cases with BAV or aortic dilatation without BAV.
AB - Aim: To determine the prevalence of unidentified bicuspid aortic valve (BAV) or aortic dilatation (>. 40. mm) in first degree relatives (FDR) of patients with isolated BAV in a general hospital. Methods and results: Patients with isolated BAV received information advising cardiac screening of their FDR. Referred and screened were 134 FDR of 54 adult index patients with isolated BAV (median 2 per index patient). FDR's mean age was 49. years (range 16-83. years) and 41% were male. They comprised 5 parents (3.7%), 52 siblings (39%) and 77 offspring (57%). Among these FDR, the prevalence of BAV was 6.0% (8 patients). In FDR without BAV, 10 (7.5%) had aortic dilatation. 'Familial BAV' was present in 9/54 families (17%). Conclusion: In a general hospital, screening of FDR of patients with isolated BAV resulted in a substantial yield of 13% new cases with BAV or aortic dilatation without BAV.
KW - Bicuspid aortic valve
KW - Congenital heart disease
KW - Family screening
UR - http://www.scopus.com/inward/record.url?scp=85040131611&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2017.12.046
DO - 10.1016/j.ijcard.2017.12.046
M3 - Article
AN - SCOPUS:85040131611
SN - 0167-5273
VL - 255
SP - 55
EP - 58
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -