X-chromosome inactivation in patients who have pigmented villonodular synovitis

R J Sakkers, D de Jong, R O van der Heul

Research output: Contribution to journalArticleAcademicpeer-review


We performed a histological examination and DNA analysis on samples of tissue from a forty-seven-year-old woman who had a clinical diagnosis of pigmented villonodular synovitis. The histological examination confirmed the diagnosis. The evaluation of the samples of tissue with preferential X-chromosome inactivation analysis (a molecular biological method for the study of clonality in tumors) showed that the lesion was polyclonal in origin. We concluded, therefore, that pigmented villonodular synovitis is more likely to be a reactive process than a true neoplasm.

Original languageEnglish
Pages (from-to)1532-6
Number of pages5
JournalJournal of Bone and Joint Surgery. American volume
Issue number10
Publication statusPublished - Dec 1991
Externally publishedYes


  • Blotting, Southern
  • DNA/analysis
  • Dosage Compensation, Genetic
  • Female
  • Humans
  • Middle Aged
  • Synovial Membrane/chemistry
  • Synovitis, Pigmented Villonodular/genetics


Dive into the research topics of 'X-chromosome inactivation in patients who have pigmented villonodular synovitis'. Together they form a unique fingerprint.

Cite this