Abstract
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/beta-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
| Translated title of the contribution | Wnt/beta-catenin signaling and disease. |
|---|---|
| Original language | Undefined/Unknown |
| Pages (from-to) | 1192-205 |
| Number of pages | 14 |
| Journal | Cell |
| Volume | 149 |
| Issue number | 6 |
| Publication status | Published - 2012 |