Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Kai Kretzschmar, Hans Clevers*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector β-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.

Original languageEnglish
Pages (from-to)273-282
Number of pages10
JournalDevelopmental Biology
Issue number2
Publication statusPublished - 15 Aug 2017


  • Adult Stem Cells
  • Animals
  • Cell Self Renewal
  • Epidermis
  • Epithelial Cells
  • Humans
  • Intestinal Mucosa
  • Models, Biological
  • Wnt Signaling Pathway
  • beta Catenin
  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't


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