Wnt/β-catenin signaling during cardiac development and repair

Jan W. Buikema*, Peter Paul M. Zwetsloot, Pieter A. Doevendans, Ibrahim J. Domian, Joost P.G. Sluijter

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Active Wnt/β-catenin signaling is essential for proper cardiac specification, progenitor expansion and myocardial growth. During development, the mass of the embryonic heart increases multiple times to achieve the dimensions of adult ventricular chambers. Cell division in the embryonic heart is fairly present, whereas cell turnover in the adult myocardium is extremely low. Understanding of embryonic cardiomyocyte cell-replication, therefore, could improve strategies for cardiac regenerative therapeutics. Here, we review which role Wnt signaling plays in cardiac development and highlight a selection of attempts that have been made to modulate Wnt signaling after cardiac ischemic injury to improve cardiac function and reduce infarct size.

Original languageEnglish
Pages (from-to)98-110
Number of pages13
JournalJournal of Cardiovascular Development and Disease
Issue number1
Publication statusPublished - Jun 2014


  • Cardiomyocyte proliferation
  • Development
  • Heart
  • Regenerative medicine
  • Wnt/β-catenin


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