Why is Pancreatic Cancer so Deadly?: The Pathologist's View

Ralph H Hruban; Matthias M Gaida; Elizabeth Thompson; Seung-Mo Hong; Michaël Nöe; Lodewijk A A Brosens; Martine Jongepier; G Johan A Offerhaus; Laura D Wood

doi:10.1002/path.5260

Why is Pancreatic Cancer so Deadly? The Pathologist's View

Ralph H Hruban
, Matthias M Gaida
, Elizabeth Thompson
, Seung-Mo Hong
, Michaël Nöe
, Lodewijk A A Brosens
, Martine Jongepier
, G Johan A Offerhaus
, Laura D Wood

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	131-141
Number of pages	11
Journal	Journal of Pathology
Volume	248
Issue number	2
Early online date	5 Mar 2019
DOIs	https://doi.org/10.1002/path.5260
Publication status	Published - Jun 2019

Keywords

pancreas
pancreas cancer
pancreatic cancer
prognosis
tumor immune microenvironment
vein
venous invasion

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10.1002/path.5260

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title = "Why is Pancreatic Cancer so Deadly?: The Pathologist's View",

abstract = "The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease. Copyright {\textcopyright} 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley \& Sons, Ltd.",

keywords = "pancreas, pancreas cancer, pancreatic cancer, prognosis, tumor immune microenvironment, vein, venous invasion",

author = "Hruban, \{Ralph H\} and Gaida, \{Matthias M\} and Elizabeth Thompson and Seung-Mo Hong and Micha{\"e}l N{\"o}e and Brosens, \{Lodewijk A A\} and Martine Jongepier and Offerhaus, \{G Johan A\} and Wood, \{Laura D\}",

note = "Copyright {\textcopyright} 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley \& Sons, Ltd.",

year = "2019",

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doi = "10.1002/path.5260",

language = "English",

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T1 - Why is Pancreatic Cancer so Deadly?

T2 - The Pathologist's View

AU - Hruban, Ralph H

AU - Gaida, Matthias M

AU - Thompson, Elizabeth

AU - Hong, Seung-Mo

AU - Nöe, Michaël

AU - Brosens, Lodewijk A A

AU - Jongepier, Martine

AU - Offerhaus, G Johan A

AU - Wood, Laura D

PY - 2019/6

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N2 - The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

AB - The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

KW - pancreas

KW - pancreas cancer

KW - pancreatic cancer

KW - prognosis

KW - tumor immune microenvironment

KW - vein

KW - venous invasion

UR - https://www.scopus.com/pages/publications/85064552420

U2 - 10.1002/path.5260

DO - 10.1002/path.5260

M3 - Article

C2 - 30838636

SN - 0022-3417

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SP - 131

EP - 141

JO - Journal of Pathology

JF - Journal of Pathology

IS - 2

ER -

Why is Pancreatic Cancer so Deadly? The Pathologist's View

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Keywords

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