White paper on the current state of imaging biomarkers in paediatric oncology

Rutger A J Nievelstein; Lise Borgwardt; Emilio J Inarejos Clemente; Thekla Von Kalle; Martin Kyncl; Maarten H Lequin; Annemieke S Littooij; Erika Pace; Pier L Di Paolo; Rick R Van Rijn; Julian M M Rogasch; Jurgen Schäfer; Irmina Sefic Pasic; Anita Spezzacatene; Nelleke Tolboom; Simon M Wan; Pietro Zucchetta

doi:10.1007/s00247-025-06372-6

White paper on the current state of imaging biomarkers in paediatric oncology

Rutger A J Nievelstein^*
, Lise Borgwardt
, Emilio J Inarejos Clemente
, Thekla Von Kalle
, Martin Kyncl
, Maarten H Lequin
, Annemieke S Littooij
, Erika Pace
, Pier L Di Paolo
, Rick R Van Rijn
, Julian M M Rogasch
, Jurgen Schäfer
, Irmina Sefic Pasic
, Anita Spezzacatene
, Nelleke Tolboom
, Simon M Wan
, Pietro Zucchetta

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

Original language	English
Pages (from-to)	2493–2507
Number of pages	15
Journal	Pediatric radiology
Volume	55
Issue number	12
Early online date	2 Sept 2025
DOIs	https://doi.org/10.1007/s00247-025-06372-6
Publication status	Published - 2025

Keywords

Biomarkers
Child
Diagnostic imaging
Nuclear medicine
Oncology
Radiology
Radionuclide imaging

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Nievelstein, R. A. J., Borgwardt, L., Inarejos Clemente, E. J., Von Kalle, T., Kyncl, M., Lequin, M. H., Littooij, A. S., Pace, E., Di Paolo, P. L., Van Rijn, R. R., Rogasch, J. M. M., Schäfer, J., Sefic Pasic, I., Spezzacatene, A., Tolboom, N., Wan, S. M., & Zucchetta, P. (2025). White paper on the current state of imaging biomarkers in paediatric oncology. Pediatric radiology, 55(12), 2493–2507. https://doi.org/10.1007/s00247-025-06372-6

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title = "White paper on the current state of imaging biomarkers in paediatric oncology",

abstract = "In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.",

keywords = "Biomarkers, Child, Diagnostic imaging, Nuclear medicine, Oncology, Radiology, Radionuclide imaging",

author = "Nievelstein, \{Rutger A J\} and Lise Borgwardt and \{Inarejos Clemente\}, \{Emilio J\} and \{Von Kalle\}, Thekla and Martin Kyncl and Lequin, \{Maarten H\} and Littooij, \{Annemieke S\} and Erika Pace and \{Di Paolo\}, \{Pier L\} and \{Van Rijn\}, \{Rick R\} and Rogasch, \{Julian M M\} and Jurgen Sch{\"a}fer and \{Sefic Pasic\}, Irmina and Anita Spezzacatene and Nelleke Tolboom and Wan, \{Simon M\} and Pietro Zucchetta",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

doi = "10.1007/s00247-025-06372-6",

language = "English",

volume = "55",

pages = "2493–2507",

journal = "Pediatric radiology",

issn = "0301-0449",

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number = "12",

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Nievelstein, RAJ, Borgwardt, L, Inarejos Clemente, EJ, Von Kalle, T, Kyncl, M, Lequin, MH, Littooij, AS, Pace, E, Di Paolo, PL, Van Rijn, RR, Rogasch, JMM, Schäfer, J, Sefic Pasic, I, Spezzacatene, A, Tolboom, N, Wan, SM & Zucchetta, P 2025, 'White paper on the current state of imaging biomarkers in paediatric oncology', Pediatric radiology, vol. 55, no. 12, pp. 2493–2507. https://doi.org/10.1007/s00247-025-06372-6

TY - JOUR

T1 - White paper on the current state of imaging biomarkers in paediatric oncology

AU - Nievelstein, Rutger A J

AU - Borgwardt, Lise

AU - Inarejos Clemente, Emilio J

AU - Von Kalle, Thekla

AU - Kyncl, Martin

AU - Lequin, Maarten H

AU - Littooij, Annemieke S

AU - Pace, Erika

AU - Di Paolo, Pier L

AU - Van Rijn, Rick R

AU - Rogasch, Julian M M

AU - Schäfer, Jurgen

AU - Sefic Pasic, Irmina

AU - Spezzacatene, Anita

AU - Tolboom, Nelleke

AU - Wan, Simon M

AU - Zucchetta, Pietro

PY - 2025

Y1 - 2025

N2 - In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

AB - In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

KW - Biomarkers

KW - Child

KW - Diagnostic imaging

KW - Nuclear medicine

KW - Oncology

KW - Radiology

KW - Radionuclide imaging

UR - https://www.scopus.com/pages/publications/105015099518

U2 - 10.1007/s00247-025-06372-6

DO - 10.1007/s00247-025-06372-6

M3 - Review article

C2 - 40892085

SN - 0301-0449

VL - 55

SP - 2493

EP - 2507

JO - Pediatric radiology

JF - Pediatric radiology

IS - 12

ER -

White paper on the current state of imaging biomarkers in paediatric oncology

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