When push comes to shove: How chromosomes absorb spindle forces without losing grip

Geert J P L Kops

doi:10.1083/jcb.202608030

When push comes to shove: How chromosomes absorb spindle forces without losing grip

Geert J P L Kops

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Chromosomes withstand substantial forces from spindle microtubules prior to their segregation in mitosis. Using super resolution live imaging, Tran, Dumont, and colleagues (https://doi.org/10.1083/jcb.202512154) find that stiff linkages between chromosomes and microtubules coupled with pliable underlying centromeres enables force absorption while maintaining a robust grip on microtubules.

Original language	English
Journal	The Journal of cell biology
Volume	225
Issue number	10
Early online date	7 Sept 2026
DOIs	https://doi.org/10.1083/jcb.202608030
Publication status	Published - 5 Oct 2026

Keywords

Spindle Apparatus/metabolism
Microtubules/metabolism
Animals
Chromosomes/metabolism
Humans
Mitosis
Chromosome Segregation
Centromere/metabolism

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10.1083/jcb.202608030

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jcb_202608030
Final published version, 1.34 MB
Licence: Taverne
Embargo ends: 07/03/2027 00:00 CET

Cite this

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title = "When push comes to shove: How chromosomes absorb spindle forces without losing grip",

abstract = "Chromosomes withstand substantial forces from spindle microtubules prior to their segregation in mitosis. Using super resolution live imaging, Tran, Dumont, and colleagues (https://doi.org/10.1083/jcb.202512154) find that stiff linkages between chromosomes and microtubules coupled with pliable underlying centromeres enables force absorption while maintaining a robust grip on microtubules.",

keywords = "Spindle Apparatus/metabolism, Microtubules/metabolism, Animals, Chromosomes/metabolism, Humans, Mitosis, Chromosome Segregation, Centromere/metabolism",

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KW - Spindle Apparatus/metabolism

KW - Microtubules/metabolism

KW - Animals

KW - Chromosomes/metabolism

KW - Humans

KW - Mitosis

KW - Chromosome Segregation

KW - Centromere/metabolism

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VL - 225

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When push comes to shove: How chromosomes absorb spindle forces without losing grip

Abstract

Keywords

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