@article{4790656467bf46aea7d73fffb31ccc94,
title = "Wall Teichoic Acid in Staphylococcus aureus Host Interaction",
abstract = "Staphylococcus aureus is a major opportunistic human pathogen that frequently causes disease in community and hospital settings. Nasal colonization is an important risk factor for developing invasive disease. Cell wall-associated glycopolymers called wall teichoic acids (WTAs) contribute to efficient nasal colonization by S. aureus. In addition, WTAs are key targets of the host immune system due to their accessibility and high abundance on the S. aureus cell surface. In this review we discuss the new insights into interactions between the host and S. aureus WTA and the implications of these interactions for preventative and therapeutic approaches against S. aureus-mediated disease.",
keywords = "colonization, infection, innate immunity, Staphylococcus aureus, vaccination, wall teichoic acid",
author = "{van Dalen}, Rob and Andreas Peschel and {van Sorge}, {Nina M}",
note = "Funding Information: The authors thank Dr Libera Lo Presti (University of T{\"u}bingen) for critical feedback on the manuscript. R.v.D. is supported by the European Molecular Biology Organization. R.v.D. and A.P. acknowledge infrastructural support by the Cluster of Excellence {\textquoteleft}Controlling Microbes to Fight Infections{\textquoteright} (EXC 2124) of the German Research Foundation (DFG). A.P. is additionally supported by DFG grants TRR156, TRR267, PE 805/5-2, and PE 805/7-1. N.M.v.S. is supported by a Vici grant (DRESSCODE; 0915018190001) from the Dutch Research Council (NWO). Figure 2 was created with Biorender.com. Funding Information: The authors thank Dr Libera Lo Presti (University of T{\"u}bingen) for critical feedback on the manuscript. R.v.D. is supported by the European Molecular Biology Organization . R.v.D. and A.P. acknowledge infrastructural support by the Cluster of Excellence {\textquoteleft}Controlling Microbes to Fight Infections{\textquoteright} ( EXC 2124 ) of the German Research Foundation (DFG). A.P. is additionally supported by DFG grants TRR156 , TRR267 , PE 805/5-2 , and PE 805/7-1 . N.M.v.S. is supported by a Vici grant (DRESSCODE; 0915018190001 ) from the Dutch Research Council (NWO) . Figure 2 was created with Biorender.com . Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = dec,
doi = "10.1016/j.tim.2020.05.017",
language = "English",
volume = "28",
pages = "985--998",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "12",
}