Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)

Alison M. Mondul; Irene M. Shui; Kai Yu; Stephanie J. Weinstein; Konstantinos K. Tsilidis; Amit D. Joshi; Antonio Agudo; Christine D. Berg; Amanda Black; Julie E. Buring; Daniel I. Chasman; Mia M. Gaudet; Christopher Haiman; Susan E. Hankinson; Brian E. Henderson; Robert N. Hoover; David J. Hunter; Kay-Tee Khaw; Tilman Kuehn; Marina Kvaskoff; Loic Le Marchand; Sara Lindstroem; Marjorie L. McCullough; Kim Overvad; Petra H. Peeters; Elio Riboli; Paul M. Ridker; Daniel O. Stram; Malin Sund; Dimitrios Trichopoulos; Rosario Tumino; Elisabete Weiderpass; Walter Willett; Peter Kraft; Regina G. Ziegler; Demetrius Albanes

doi:10.1158/1055-9965.EPI-14-1127

Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)

Alison M. Mondul^*, Irene M. Shui, Kai Yu, Stephanie J. Weinstein, Konstantinos K. Tsilidis, Amit D. Joshi, Antonio Agudo, Christine D. Berg, Amanda Black, Julie E. Buring, Daniel I. Chasman, Mia M. Gaudet, Christopher Haiman, Susan E. Hankinson, Brian E. Henderson, Robert N. Hoover, David J. Hunter, Kay-Tee Khaw, Tilman Kuehn, Marina KvaskoffLoic Le Marchand, Sara Lindstroem, Marjorie L. McCullough, Kim Overvad, Petra H. Peeters, Elio Riboli, Paul M. Ridker, Daniel O. Stram, Malin Sund, Dimitrios Trichopoulos, Rosario Tumino, Elisabete Weiderpass, Walter Willett, Peter Kraft, Regina G. Ziegler, Demetrius Albanes

^*Corresponding author for this work

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH) D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.

Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25 (OH) D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.

Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.

Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH) D-related genotypes, and breast cancer risk.

Impact: These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer. (c) 2014 AACR.

Original language	English
Pages (from-to)	627-630
Number of pages	4
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	24
Issue number	3
DOIs	https://doi.org/10.1158/1055-9965.EPI-14-1127
Publication status	Published - Mar 2015

Keywords

GENOME-WIDE ASSOCIATION
25-HYDROXYVITAMIN D

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Mondul, A. M., Shui, I. M., Yu, K., Weinstein, S. J., Tsilidis, K. K., Joshi, A. D., Agudo, A., Berg, C. D., Black, A., Buring, J. E., Chasman, D. I., Gaudet, M. M., Haiman, C., Hankinson, S. E., Henderson, B. E., Hoover, R. N., Hunter, D. J., Khaw, K.-T., Kuehn, T., ... Albanes, D. (2015). Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer Epidemiology Biomarkers & Prevention, 24(3), 627-630. https://doi.org/10.1158/1055-9965.EPI-14-1127

@article{d7dd9a19a00b429cb30e176a7474aa40,

title = "Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)",

abstract = "Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH) D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25 (OH) D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH) D-related genotypes, and breast cancer risk.Impact: These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer. (c) 2014 AACR.",

keywords = "GENOME-WIDE ASSOCIATION, 25-HYDROXYVITAMIN D",

author = "Mondul, {Alison M.} and Shui, {Irene M.} and Kai Yu and Weinstein, {Stephanie J.} and Tsilidis, {Konstantinos K.} and Joshi, {Amit D.} and Antonio Agudo and Berg, {Christine D.} and Amanda Black and Buring, {Julie E.} and Chasman, {Daniel I.} and Gaudet, {Mia M.} and Christopher Haiman and Hankinson, {Susan E.} and Henderson, {Brian E.} and Hoover, {Robert N.} and Hunter, {David J.} and Kay-Tee Khaw and Tilman Kuehn and Marina Kvaskoff and {Le Marchand}, Loic and Sara Lindstroem and McCullough, {Marjorie L.} and Kim Overvad and Peeters, {Petra H.} and Elio Riboli and Ridker, {Paul M.} and Stram, {Daniel O.} and Malin Sund and Dimitrios Trichopoulos and Rosario Tumino and Elisabete Weiderpass and Walter Willett and Peter Kraft and Ziegler, {Regina G.} and Demetrius Albanes",

year = "2015",

month = mar,

doi = "10.1158/1055-9965.EPI-14-1127",

language = "English",

volume = "24",

pages = "627--630",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "3",

}

Mondul, AM, Shui, IM, Yu, K, Weinstein, SJ, Tsilidis, KK, Joshi, AD, Agudo, A, Berg, CD, Black, A, Buring, JE, Chasman, DI, Gaudet, MM, Haiman, C, Hankinson, SE, Henderson, BE, Hoover, RN, Hunter, DJ, Khaw, K-T, Kuehn, T, Kvaskoff, M, Le Marchand, L, Lindstroem, S, McCullough, ML, Overvad, K, Peeters, PH, Riboli, E, Ridker, PM, Stram, DO, Sund, M, Trichopoulos, D, Tumino, R, Weiderpass, E, Willett, W, Kraft, P, Ziegler, RG & Albanes, D 2015, 'Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)', Cancer Epidemiology Biomarkers & Prevention, vol. 24, no. 3, pp. 627-630. https://doi.org/10.1158/1055-9965.EPI-14-1127

TY - JOUR

T1 - Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)

AU - Mondul, Alison M.

AU - Shui, Irene M.

AU - Yu, Kai

AU - Weinstein, Stephanie J.

AU - Tsilidis, Konstantinos K.

AU - Joshi, Amit D.

AU - Agudo, Antonio

AU - Berg, Christine D.

AU - Black, Amanda

AU - Buring, Julie E.

AU - Chasman, Daniel I.

AU - Gaudet, Mia M.

AU - Haiman, Christopher

AU - Hankinson, Susan E.

AU - Henderson, Brian E.

AU - Hoover, Robert N.

AU - Hunter, David J.

AU - Khaw, Kay-Tee

AU - Kuehn, Tilman

AU - Kvaskoff, Marina

AU - Le Marchand, Loic

AU - Lindstroem, Sara

AU - McCullough, Marjorie L.

AU - Overvad, Kim

AU - Peeters, Petra H.

AU - Riboli, Elio

AU - Ridker, Paul M.

AU - Stram, Daniel O.

AU - Sund, Malin

AU - Trichopoulos, Dimitrios

AU - Tumino, Rosario

AU - Weiderpass, Elisabete

AU - Willett, Walter

AU - Kraft, Peter

AU - Ziegler, Regina G.

AU - Albanes, Demetrius

PY - 2015/3

Y1 - 2015/3

N2 - Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH) D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25 (OH) D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH) D-related genotypes, and breast cancer risk.Impact: These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer. (c) 2014 AACR.

AB - Background: Two recent genome-wide association studies (GWAS) identified SNPs in or near four genes related to circulating 25-hydroxyvitamin D [25(OH) D] concentration. To examine the hypothesized inverse relationship between vitamin D status and breast cancer, we studied the associations between SNPs in these genes and breast cancer risk in a large pooled study of 9,456 cases and 10,816 controls from six cohorts.Methods: SNP markers localized to each of four genes (GC, CYP24A1, CYP2R1, and DHCR7) previously associated with 25 (OH) D were genotyped and examined both individually and as a 4-SNP polygenic score. Logistic regression was used to estimate the associations between the genetic variants and risk of breast cancer.Results: We found no association between any of the four SNPs or their polygenic score and breast cancer risk.Conclusions: Our findings do not support an association between vitamin D status, as reflected by 25(OH) D-related genotypes, and breast cancer risk.Impact: These findings may contribute to future meta-analyses and scientific review articles, and provide new data about the association between vitamin D-related genes and breast cancer. (c) 2014 AACR.

KW - GENOME-WIDE ASSOCIATION

KW - 25-HYDROXYVITAMIN D

U2 - 10.1158/1055-9965.EPI-14-1127

DO - 10.1158/1055-9965.EPI-14-1127

M3 - Article

C2 - 25542828

SN - 1055-9965

VL - 24

SP - 627

EP - 630

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 3

ER -

Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3)

Abstract

Keywords

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