Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study

Raffaella Valenti; Andreas Charidimou; Li Xiong; Gregoire Boulouis; Panagiotis Fotiadis; Alison Ayres; Grace Riley; Hugo J. Kuijf; Yael D. Reijmer; Leonardo Pantoni; M. Edip Gurol; Sigurros Davidsdottir; Steven M. Greenberg; Anand Viswanathan

doi:10.3233/JAD-160927

Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study

Raffaella Valenti, Andreas Charidimou, Li Xiong, Gregoire Boulouis, Panagiotis Fotiadis, Alison Ayres, Grace Riley, Hugo J. Kuijf, Yael D. Reijmer, Leonardo Pantoni, M. Edip Gurol, Sigurros Davidsdottir, Steven M. Greenberg, Anand Viswanathan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23 on Benton Facial Recognition Test [BFRT] and 13.6 on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.

Original language	English
Pages (from-to)	1223-1227
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	56
Issue number	4
DOIs	https://doi.org/10.3233/JAD-160927
Publication status	Published - 2017

Keywords

Cerebral amyloid angiopathy
Neuroimaging markers
Neuropsychological assessment
Visuospatial functioning

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10.3233/JAD-160927

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@article{b1d7f5fec4284884822c2578ac56b93d,

title = "Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study",

abstract = "Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23 on Benton Facial Recognition Test [BFRT] and 13.6 on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.",

keywords = "Cerebral amyloid angiopathy, Neuroimaging markers, Neuropsychological assessment, Visuospatial functioning",

author = "Raffaella Valenti and Andreas Charidimou and Li Xiong and Gregoire Boulouis and Panagiotis Fotiadis and Alison Ayres and Grace Riley and Kuijf, {Hugo J.} and Reijmer, {Yael D.} and Leonardo Pantoni and Gurol, {M. Edip} and Sigurros Davidsdottir and Greenberg, {Steven M.} and Anand Viswanathan",

note = "Funding Information: ACKNOWLEDGMENTS This work was supported by the NIH (grants R01AG047975, R01AG026484, P50AG005134, K23AG02872605).",

year = "2017",

doi = "10.3233/JAD-160927",

language = "English",

volume = "56",

pages = "1223--1227",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "4",

}

TY - JOUR

T1 - Visuospatial Functioning in Cerebral Amyloid Angiopathy

T2 - A Pilot Study

AU - Valenti, Raffaella

AU - Charidimou, Andreas

AU - Xiong, Li

AU - Boulouis, Gregoire

AU - Fotiadis, Panagiotis

AU - Ayres, Alison

AU - Riley, Grace

AU - Kuijf, Hugo J.

AU - Reijmer, Yael D.

AU - Pantoni, Leonardo

AU - Gurol, M. Edip

AU - Davidsdottir, Sigurros

AU - Greenberg, Steven M.

AU - Viswanathan, Anand

N1 - Funding Information: ACKNOWLEDGMENTS This work was supported by the NIH (grants R01AG047975, R01AG026484, P50AG005134, K23AG02872605).

PY - 2017

Y1 - 2017

N2 - Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23 on Benton Facial Recognition Test [BFRT] and 13.6 on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.

AB - Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23 on Benton Facial Recognition Test [BFRT] and 13.6 on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds. This pilot study highlights the presence of visual-processing deficits in CAA. The impairment could be related to global disease severity in addition to local brain injury.

KW - Cerebral amyloid angiopathy

KW - Neuroimaging markers

KW - Neuropsychological assessment

KW - Visuospatial functioning

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U2 - 10.3233/JAD-160927

DO - 10.3233/JAD-160927

M3 - Article

C2 - 28222510

AN - SCOPUS:85013405001

SN - 1387-2877

VL - 56

SP - 1223

EP - 1227

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 4

ER -

Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study

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