TY - JOUR
T1 - Visual deficit possibly caused by lutetium-177 PSMA treatment
AU - van Kalmthout, Ludwike
AU - Stam, Anine
AU - Gans, Renze
AU - Lam, Marnix
N1 - Publisher Copyright:
© BMJ Publishing Group Limited 2018. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2018
Y1 - 2018
N2 - This report describes a case of a 54-year-old man who underwent lutetium-177-PSMA therapy in the setting of metastatic castration-resistant prostate cancer (mCRPC) in the University Medical Center Utrecht. Following administration of the second cycle, patient presented with a slowly impairing, bilateral visual loss. This clinical presentation was most likely the result of the high intracranial pressure due to impediment of cerebrospinal fluid circulation, possibly related to obstructive dural thickness, being either caused by dural and/or leptomeningeal metastases of advanced mCRPC or by local radiation effects following lutetium-177-PSMA therapy. Describing this case, we aim to add to the discussion on 177Lu-PSMA safety, in which prospective research will ultimately offer definite answers.
AB - This report describes a case of a 54-year-old man who underwent lutetium-177-PSMA therapy in the setting of metastatic castration-resistant prostate cancer (mCRPC) in the University Medical Center Utrecht. Following administration of the second cycle, patient presented with a slowly impairing, bilateral visual loss. This clinical presentation was most likely the result of the high intracranial pressure due to impediment of cerebrospinal fluid circulation, possibly related to obstructive dural thickness, being either caused by dural and/or leptomeningeal metastases of advanced mCRPC or by local radiation effects following lutetium-177-PSMA therapy. Describing this case, we aim to add to the discussion on 177Lu-PSMA safety, in which prospective research will ultimately offer definite answers.
KW - prostate cancer
KW - unwanted effects / adverse reactions
UR - http://www.scopus.com/inward/record.url?scp=85054709177&partnerID=8YFLogxK
U2 - 10.1136/bcr-2018-225508
DO - 10.1136/bcr-2018-225508
M3 - Article
C2 - 30301726
SN - 1757-790X
VL - 2018
JO - BMJ Case Reports [E]
JF - BMJ Case Reports [E]
M1 - 225508
ER -