Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy

K. M. Dolman; A. E.G.Kr von dem Borne; R. Goldschmeding; R. D.B. Gans; Aj M. Donker; Th J. Vervaat; G. Zevenbergen; D. Maingay; R. E. Nikkels; A. E.G.Kr von dem Borne; R. Goldschmeding

doi:10.1016/0140-6736(93)91761-A

Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy

K. M. Dolman, A. E.G.Kr von dem Borne, R. Goldschmeding, R. D.B. Gans, Aj M. Donker, Th J. Vervaat, G. Zevenbergen, D. Maingay, R. E. Nikkels, A. E.G.Kr von dem Borne, R. Goldschmeding

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Abstract

Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely.

Original language	English
Pages (from-to)	651-652
Number of pages	2
Journal	The Lancet
Volume	342
Issue number	8872
DOIs	https://doi.org/10.1016/0140-6736(93)91761-A
Publication status	Published - 11 Sept 1993

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Dolman, K. M., von dem Borne, A. E. G. K., Goldschmeding, R., Gans, R. D. B., Donker, A. M., Vervaat, T. J., Zevenbergen, G., Maingay, D., Nikkels, R. E., von dem Borne, A. E. G. K., & Goldschmeding, R. (1993). Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. The Lancet, 342(8872), 651-652. https://doi.org/10.1016/0140-6736(93)91761-A

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abstract = "Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely.",

author = "Dolman, {K. M.} and {von dem Borne}, {A. E.G.Kr} and R. Goldschmeding and Gans, {R. D.B.} and Donker, {Aj M.} and Vervaat, {Th J.} and G. Zevenbergen and D. Maingay and Nikkels, {R. E.} and {von dem Borne}, {A. E.G.Kr} and R. Goldschmeding",

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doi = "10.1016/0140-6736(93)91761-A",

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AU - Dolman, K. M.

AU - von dem Borne, A. E.G.Kr

AU - Goldschmeding, R.

AU - Gans, R. D.B.

AU - Donker, Aj M.

AU - Vervaat, Th J.

AU - Zevenbergen, G.

AU - Maingay, D.

AU - Nikkels, R. E.

AU - von dem Borne, A. E.G.Kr

AU - Goldschmeding, R.

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AB - Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely.

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Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy

Abstract

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