Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women: The hidden players. A mini review

Aisha Gohar, Dominique P.V. de Kleijn, Arno W. Hoes, Frans H. Rutten, Denise Hilfiker-Kleiner, Péter Ferdinandy, Joost P.G. Sluijter, Hester M. den Ruijter*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Left ventricular diastolic dysfunction, the main feature of heart failure with preserved ejection fraction (HFpEF), is thought to be primarily caused by comorbidities affecting the endothelial function of the coronary microvasculature. Circulating extracellular vesicles, released by the endothelium have been postulated to reflect endothelial damage. Therefore, we reviewed the role of extracellular vesicles, in particularly endothelium microparticles, in these comorbidities, including obesity and hypertension, to identify if they may be potential markers of the endothelial dysfunction underlying left ventricular diastolic dysfunction and HFpEF.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalVascular Pharmacology
Volume111
Early online date2018
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Comorbidities
  • Endothelial microparticles
  • HFpEF
  • LVD
  • Sex

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