TY - JOUR
T1 - Vascular extracellular vesicles in comorbidities of heart failure with preserved ejection fraction in men and women
T2 - The hidden players. A mini review
AU - Gohar, Aisha
AU - de Kleijn, Dominique P.V.
AU - Hoes, Arno W.
AU - Rutten, Frans H.
AU - Hilfiker-Kleiner, Denise
AU - Ferdinandy, Péter
AU - Sluijter, Joost P.G.
AU - den Ruijter, Hester M.
N1 - Publisher Copyright:
© 2018
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Left ventricular diastolic dysfunction, the main feature of heart failure with preserved ejection fraction (HFpEF), is thought to be primarily caused by comorbidities affecting the endothelial function of the coronary microvasculature. Circulating extracellular vesicles, released by the endothelium have been postulated to reflect endothelial damage. Therefore, we reviewed the role of extracellular vesicles, in particularly endothelium microparticles, in these comorbidities, including obesity and hypertension, to identify if they may be potential markers of the endothelial dysfunction underlying left ventricular diastolic dysfunction and HFpEF.
AB - Left ventricular diastolic dysfunction, the main feature of heart failure with preserved ejection fraction (HFpEF), is thought to be primarily caused by comorbidities affecting the endothelial function of the coronary microvasculature. Circulating extracellular vesicles, released by the endothelium have been postulated to reflect endothelial damage. Therefore, we reviewed the role of extracellular vesicles, in particularly endothelium microparticles, in these comorbidities, including obesity and hypertension, to identify if they may be potential markers of the endothelial dysfunction underlying left ventricular diastolic dysfunction and HFpEF.
KW - Comorbidities
KW - Endothelial microparticles
KW - HFpEF
KW - LVD
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=85054437843&partnerID=8YFLogxK
U2 - 10.1016/j.vph.2018.05.006
DO - 10.1016/j.vph.2018.05.006
M3 - Review article
C2 - 29807165
SN - 1537-1891
VL - 111
SP - 1
EP - 6
JO - Vascular Pharmacology
JF - Vascular Pharmacology
ER -