Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery

Matteo Demuru, Willemiek Zweiphenning, Dorien van Blooijs, Pieter Van Eijsden, Frans Leijten, Maeike Zijlmans, Stiliyan Kalitzin

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


Objective. A ‘Virtual resection’ consists of computationally simulating the effect of an actual resection on the brain. We validated two functional connectivity based virtual resection methods with the actual connectivity measured using post-resection intraoperative recordings. Approach. A non-linear association index was applied to pre-resection recordings from 11 extra-temporal focal epilepsy patients. We computed two virtual resection strategies: first, a ‘naive’ one obtained by simply removing from the connectivity matrix the electrodes that were resected; second, a virtual resection with partialization accounting for the influence of resected electrodes on not-resected electrodes. We validated the virtual resections with two analysis: (1) we tested with a Kolmogorov-Smirnov test if the distributions of connectivity values after the virtual resections differed from the actual post-resection connectivity distribution; (2) we tested if the overall effect of the resection measured by contrasting pre-resection and post-resection connectivity values is detectable with the virtual resection approach using a Kolmogorv-Smirnov test. Main results. The estimation of post-resection connectivity values did not succeed for both methods. In the second analysis, the naive method failed completely to detect the effect found between pre-resection and post-resection connectivity distributions, while the partialization method agreed with post-resection measurements in detecting a drop connectivity compared to pre-resection recordings. Our findings suggest that the partialization technique is superior to the naive method in detecting the overall effect after the resection. Significance. We pointed out how a realistic validation based on actual post-resection recordings reveals that virtual resection methods are not yet mature to inform the clinical decision-making.

Original languageEnglish
Article number066002
Pages (from-to)1-10
JournalJournal of Neural Engineering
Issue number6
Early online date21 Oct 2020
Publication statusPublished - 11 Nov 2020


  • Enter electrocorticography
  • Epilepsy surgery
  • Epileptogenic zone localization
  • Functional connectivity
  • Network neuroscience
  • Virtual resection


Dive into the research topics of 'Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery'. Together they form a unique fingerprint.

Cite this