Use of Pulmonary Inhalants Remains Remarkably High After Atrial Septal Defect Closure

Martina Nassif; Odilia I Woudstra; Joey M Kuijpers; Peter J Sterk; Reindert P van Steenwijk; Aeilko H Zwinderman; Berto J Bouma; Robbert J de Winter

doi:10.1253/circj.CJ-18-0613

Use of Pulmonary Inhalants Remains Remarkably High After Atrial Septal Defect Closure

Martina Nassif, Odilia I Woudstra, Joey M Kuijpers, Peter J Sterk, Reindert P van Steenwijk, Aeilko H Zwinderman, Berto J Bouma, Robbert J de Winter

Department of Cardiology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Post-repair atrial septal defects (ASD) patients are frequently discharged from follow-up, but the extent of pulmonary symptoms long-term post-repair is unknown. Methods and Results: The national CONgenital CORvitia registry was linked to the national Drug Registry to investigate all ambulatory-dispensed pulmonary inhalants for 2006–2014. ASD patients were compared with age-and sex-matched referents from the general population. A total of 1,959 adult patients (age 42±17 years; 66% female; 1,223 [62%] repaired) were included. Compared with the referents, ASD patients had more inhalant use, even at long-term post-repair follow-up (OR=1.81 [95% CI 1.62–2.03]; P<0.001). Conclusions: ASD patients had 2-fold higher inhalant use compared with referents even at long-term post-repair follow-up, suggesting persistent pulmonary functional impairment.

Original language	English
Pages (from-to)	2913-2916
Number of pages	4
Journal	Circulation journal
Volume	82
Issue number	11
DOIs	https://doi.org/10.1253/circj.CJ-18-0613
Publication status	Published - 25 Oct 2018

Keywords

Administration, Inhalation
Adult
Female
Follow-Up Studies
Heart Septal Defects/complications
Humans
Lung
Lung Diseases/complications
Male
Middle Aged
Registries

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@article{00af3de257e84fa4bb4465b5e478ef94,

title = "Use of Pulmonary Inhalants Remains Remarkably High After Atrial Septal Defect Closure",

abstract = "Background: Post-repair atrial septal defects (ASD) patients are frequently discharged from follow-up, but the extent of pulmonary symptoms long-term post-repair is unknown. Methods and Results: The national CONgenital CORvitia registry was linked to the national Drug Registry to investigate all ambulatory-dispensed pulmonary inhalants for 2006–2014. ASD patients were compared with age-and sex-matched referents from the general population. A total of 1,959 adult patients (age 42±17 years; 66% female; 1,223 [62%] repaired) were included. Compared with the referents, ASD patients had more inhalant use, even at long-term post-repair follow-up (OR=1.81 [95% CI 1.62–2.03]; P<0.001). Conclusions: ASD patients had 2-fold higher inhalant use compared with referents even at long-term post-repair follow-up, suggesting persistent pulmonary functional impairment.",

keywords = "Administration, Inhalation, Adult, Female, Follow-Up Studies, Heart Septal Defects/complications, Humans, Lung, Lung Diseases/complications, Male, Middle Aged, Registries",

author = "Martina Nassif and Woudstra, {Odilia I} and Kuijpers, {Joey M} and Sterk, {Peter J} and {van Steenwijk}, {Reindert P} and Zwinderman, {Aeilko H} and Bouma, {Berto J} and {de Winter}, {Robbert J}",

year = "2018",

month = oct,

day = "25",

doi = "10.1253/circj.CJ-18-0613",

language = "English",

volume = "82",

pages = "2913--2916",

journal = "Circulation journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "11",

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TY - JOUR

T1 - Use of Pulmonary Inhalants Remains Remarkably High After Atrial Septal Defect Closure

AU - Nassif, Martina

AU - Woudstra, Odilia I

AU - Kuijpers, Joey M

AU - Sterk, Peter J

AU - van Steenwijk, Reindert P

AU - Zwinderman, Aeilko H

AU - Bouma, Berto J

AU - de Winter, Robbert J

PY - 2018/10/25

Y1 - 2018/10/25

N2 - Background: Post-repair atrial septal defects (ASD) patients are frequently discharged from follow-up, but the extent of pulmonary symptoms long-term post-repair is unknown. Methods and Results: The national CONgenital CORvitia registry was linked to the national Drug Registry to investigate all ambulatory-dispensed pulmonary inhalants for 2006–2014. ASD patients were compared with age-and sex-matched referents from the general population. A total of 1,959 adult patients (age 42±17 years; 66% female; 1,223 [62%] repaired) were included. Compared with the referents, ASD patients had more inhalant use, even at long-term post-repair follow-up (OR=1.81 [95% CI 1.62–2.03]; P<0.001). Conclusions: ASD patients had 2-fold higher inhalant use compared with referents even at long-term post-repair follow-up, suggesting persistent pulmonary functional impairment.

AB - Background: Post-repair atrial septal defects (ASD) patients are frequently discharged from follow-up, but the extent of pulmonary symptoms long-term post-repair is unknown. Methods and Results: The national CONgenital CORvitia registry was linked to the national Drug Registry to investigate all ambulatory-dispensed pulmonary inhalants for 2006–2014. ASD patients were compared with age-and sex-matched referents from the general population. A total of 1,959 adult patients (age 42±17 years; 66% female; 1,223 [62%] repaired) were included. Compared with the referents, ASD patients had more inhalant use, even at long-term post-repair follow-up (OR=1.81 [95% CI 1.62–2.03]; P<0.001). Conclusions: ASD patients had 2-fold higher inhalant use compared with referents even at long-term post-repair follow-up, suggesting persistent pulmonary functional impairment.

KW - Administration, Inhalation

KW - Adult

KW - Female

KW - Follow-Up Studies

KW - Heart Septal Defects/complications

KW - Humans

KW - Lung

KW - Lung Diseases/complications

KW - Male

KW - Middle Aged

KW - Registries

U2 - 10.1253/circj.CJ-18-0613

DO - 10.1253/circj.CJ-18-0613

M3 - Article

C2 - 30298834

SN - 1346-9843

VL - 82

SP - 2913

EP - 2916

JO - Circulation journal

JF - Circulation journal

IS - 11

ER -

Use of Pulmonary Inhalants Remains Remarkably High After Atrial Septal Defect Closure

Abstract

Keywords

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