Abstract
Background: Vasopressin plays an essential role in osmoregulation, but has deleterious effects in patients with ADPKD. Increased water intake to suppress vasopressin activity has been suggested as a potential renoprotective strategy. This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. Methods: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR (I-125-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. Results: Ninety-four patients with ADPKD were included (56 males, age 40 +/- 10, mGFR 77 +/- 32 ml/min/1.73 m(2), TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 +/- 195, 289 +/- 7 mOsmol/l and 7.3 (3.2-14.6) pmol/l, respectively. Plasma osmolality was associated with copeptin concentration (R = 0.54, p
Original language | English |
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Pages (from-to) | 248-256 |
Number of pages | 9 |
Journal | American Journal of Nephrology |
Volume | 41 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2015 |
Externally published | Yes |
Keywords
- Autosomal dominant polycystic kidney disease
- Urine osmolality
- Plasma osmolality
- Vasopressin
- GLOMERULAR-FILTRATION-RATE
- RENAL CONCENTRATING CAPACITY
- SURROGATE MARKER
- ARGININE-VASOPRESSIN
- FUNCTION DECLINE
- CYSTIC-DISEASE
- COPEPTIN
- WATER
- PROGRESSION
- TOLVAPTAN