Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease

Niek F. Casteleijn, Debbie Zittema, Stephan J. L. Bakker, Wendy E. Boertien, Carlo A. Gaillard, Esther Meijer, Edwin M. Spithoven, Joachim Struck, Ronald Gansevoort

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Vasopressin plays an essential role in osmoregulation, but has deleterious effects in patients with ADPKD. Increased water intake to suppress vasopressin activity has been suggested as a potential renoprotective strategy. This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD patients. Methods: We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR (I-125-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed. Results: Ninety-four patients with ADPKD were included (56 males, age 40 +/- 10, mGFR 77 +/- 32 ml/min/1.73 m(2), TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 +/- 195, 289 +/- 7 mOsmol/l and 7.3 (3.2-14.6) pmol/l, respectively. Plasma osmolality was associated with copeptin concentration (R = 0.54, p
Original languageEnglish
Pages (from-to)248-256
Number of pages9
JournalAmerican Journal of Nephrology
Volume41
Issue number3
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Autosomal dominant polycystic kidney disease
  • Urine osmolality
  • Plasma osmolality
  • Vasopressin
  • GLOMERULAR-FILTRATION-RATE
  • RENAL CONCENTRATING CAPACITY
  • SURROGATE MARKER
  • ARGININE-VASOPRESSIN
  • FUNCTION DECLINE
  • CYSTIC-DISEASE
  • COPEPTIN
  • WATER
  • PROGRESSION
  • TOLVAPTAN

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