TY - JOUR
T1 - Urinary incontinence more than 15 years after premenopausal risk-reducing salpingo-oophorectomy
T2 - a multicentre cross-sectional study
AU - Terra, Lara
AU - Heemskerk-Gerritsen, Bernadette A M
AU - Beekman, Maarten J
AU - Engelhardt, Ellen
AU - Mourits, Marian J E
AU - van Doorn, Helena C
AU - de Hullu, Joanna A
AU - Mom, Constantijne H
AU - Slangen, Brigitte F M
AU - Gaarenstroom, Katja N
AU - van Beurden, Marc
AU - Roeters Van Lennep, Jeanine E
AU - van Dorst, Eleonora B L
AU - van der Kolk, Lizet E
AU - Collée, J Margriet
AU - Wevers, Marijke R
AU - Ausems, Margreet G E M
AU - van Engelen, Klaartje
AU - van de Beek, Irma
AU - Berger, Lieke P V
AU - van Asperen, Christi J
AU - Gomez Garcia, Encarna B
AU - Maas, Angela H E M
AU - Hooning, Maartje J
AU - Steensma, Anneke B
AU - van Leeuwen, Flora E
N1 - Funding Information:
The Dutch Cancer Society (KWF) and the Maarten van der Weijden foundation granted us with the funding for this project, registered under grant 10164. The funding body had no role in the design of the study, collection, analysis or interpretation of data or in writing the article.
Publisher Copyright:
© 2023 John Wiley & Sons Ltd.
PY - 2024/1
Y1 - 2024/1
N2 - OBJECTIVE: To study the impact of premenopausal risk-reducing salpingo-oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later.DESIGN: Cross-sectional study, nested in a nationwide cohort.SETTING: Multicentre in the Netherlands.POPULATION: 750 women (68% BRCA1/2 pathogenic variant carriers) who underwent either premenopausal RRSO (≤45 years, n = 496) or postmenopausal RRSO (≥54 years, n = 254). All participants were ≥55 years at the time of the study.METHODS: Urinary incontinence was assessed by the urinary distress inventory-6 (UDI-6); a score ≥33.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ-SF) was used to assess the impact on women's health-related quality of life (HR-QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders.MAIN OUTCOME MEASURES: Differences in UDI-6 scores and IIQ-SF scores between women with a premenopausal and a postmenopausal RRSO.RESULTS: Women in the premenopausal RRSO group had slightly higher UDI-6 scores compared with women in the postmenopausal RRSO group (P = 0.053), and their risk of symptomatic UI was non-significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93-4.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2-10.0) but not with urge UI. The proportions of women with a significant impact of UI on HR-QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; P = 0.46).CONCLUSIONS: More than 15 years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO.
AB - OBJECTIVE: To study the impact of premenopausal risk-reducing salpingo-oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later.DESIGN: Cross-sectional study, nested in a nationwide cohort.SETTING: Multicentre in the Netherlands.POPULATION: 750 women (68% BRCA1/2 pathogenic variant carriers) who underwent either premenopausal RRSO (≤45 years, n = 496) or postmenopausal RRSO (≥54 years, n = 254). All participants were ≥55 years at the time of the study.METHODS: Urinary incontinence was assessed by the urinary distress inventory-6 (UDI-6); a score ≥33.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ-SF) was used to assess the impact on women's health-related quality of life (HR-QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders.MAIN OUTCOME MEASURES: Differences in UDI-6 scores and IIQ-SF scores between women with a premenopausal and a postmenopausal RRSO.RESULTS: Women in the premenopausal RRSO group had slightly higher UDI-6 scores compared with women in the postmenopausal RRSO group (P = 0.053), and their risk of symptomatic UI was non-significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93-4.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2-10.0) but not with urge UI. The proportions of women with a significant impact of UI on HR-QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; P = 0.46).CONCLUSIONS: More than 15 years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO.
KW - BRCA pathogenic variant carriers
KW - health-related quality of life
KW - menopause
KW - premenopausal RRSO
KW - preventive bilateral salpingo-oophorectomy
KW - stress incontinence
KW - urge incontinence
UR - http://www.scopus.com/inward/record.url?scp=85164177288&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.17591
DO - 10.1111/1471-0528.17591
M3 - Article
C2 - 37394722
SN - 1470-0328
VL - 131
SP - 99
EP - 108
JO - BJOG - An International Journal of Obstetrics and Gynaecology
JF - BJOG - An International Journal of Obstetrics and Gynaecology
IS - 1
ER -