TY - JOUR
T1 - Upstream and Downstream Cardiovascular Changes in Rheumatic Mitral Stenosis
T2 - An Update
AU - Rudiktyo, Estu
AU - Teske, Arco J
AU - Yonas, Emir
AU - Ambari, Ade M
AU - Cramer, Maarten J
AU - Guglielmo, Marco
AU - Semino, Tommaso
AU - Siswanto, Bambang Budi
AU - Doevendans, Pieter A
AU - Soesanto, Amiliana M
PY - 2025/4/11
Y1 - 2025/4/11
N2 - Rheumatic heart disease (RHD) and its complications are major health problems worldwide, especially in developing countries, owing to their high prevalence. Mitral stenosis (MS) is one of the most common lesions in RHD, either isolated or in combination with mitral regurgitation, and eventually leads to atrial fibrillation (AF), congestive heart failure, pulmonary hypertension (PH), and other complications, including ischemic stroke or limb ischemia, if not promptly diagnosed and treated. Recent studies have suggested that MS affects the cardiovascular system beyond mere obstructions. The presence of MS in RHD causes significant changes in the cardiovascular system, both upstream and downstream, affecting both the left and right ventricles. Rheumatic MS causes significant structural changes through inflammatory pathways and hemodynamic changes, owing to its obstructive effects. This review aims to discuss the vast changes in the cardiovascular system caused by rheumatic MS.
AB - Rheumatic heart disease (RHD) and its complications are major health problems worldwide, especially in developing countries, owing to their high prevalence. Mitral stenosis (MS) is one of the most common lesions in RHD, either isolated or in combination with mitral regurgitation, and eventually leads to atrial fibrillation (AF), congestive heart failure, pulmonary hypertension (PH), and other complications, including ischemic stroke or limb ischemia, if not promptly diagnosed and treated. Recent studies have suggested that MS affects the cardiovascular system beyond mere obstructions. The presence of MS in RHD causes significant changes in the cardiovascular system, both upstream and downstream, affecting both the left and right ventricles. Rheumatic MS causes significant structural changes through inflammatory pathways and hemodynamic changes, owing to its obstructive effects. This review aims to discuss the vast changes in the cardiovascular system caused by rheumatic MS.
U2 - 10.3390/jcm14082639
DO - 10.3390/jcm14082639
M3 - Review article
C2 - 40283468
SN - 2077-0383
VL - 14
JO - Journal of Clinical medicine
JF - Journal of Clinical medicine
IS - 8
M1 - 2639
ER -