Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity

Stefan Nierkens; Lotte Spel; Dirk van der Steen; Nina Blokland; Mirjam Heemskerk; Jaap Boelens; Marianne Boes

Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity

Stefan Nierkens
, Lotte Spel
, Dirk van der Steen
, Nina Blokland
, Mirjam Heemskerk
, Jaap Boelens
, Marianne Boes

Research output: Contribution to journal › Meeting Abstract › Other research output

Abstract

Neuroblastoma is the most common solid tumor in pediatric patients, with a clear unmet need as survival rates are <20% for stage IV disease. As adjuvant immunotherapy is considered to have additional anti-tumor activity we aim to increase cytotoxic T lymphocyte (CTL)-mediated immune surveillance in neuroblastoma patients by administration of a dendritic cell-based vaccine. Neuroblastoma has developed mechanisms to circumvent CTL recognition; therefore it is our aim to find clinical strategies to make neuroblastoma susceptible for CTL killing

Original language	English
Pages (from-to)	S240-S240
Number of pages	1
Journal	Biology of Blood and Marrow Transplantation
Volume	21
Issue number	2
Publication status	Published - Feb 2015
Event	BMT Tandem Meetings - San Diego, Canada Duration: 11 Feb 2015 → 15 Feb 2015

Cite this

@article{6ce9abff9acb4e16a08b2edbc0dde9c1,

title = "Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity",

abstract = "Neuroblastoma is the most common solid tumor in pediatric patients, with a clear unmet need as survival rates are <20\% for stage IV disease. As adjuvant immunotherapy is considered to have additional anti-tumor activity we aim to increase cytotoxic T lymphocyte (CTL)-mediated immune surveillance in neuroblastoma patients by administration of a dendritic cell-based vaccine. Neuroblastoma has developed mechanisms to circumvent CTL recognition; therefore it is our aim to find clinical strategies to make neuroblastoma susceptible for CTL killing",

author = "Stefan Nierkens and Lotte Spel and \{van der Steen\}, Dirk and Nina Blokland and Mirjam Heemskerk and Jaap Boelens and Marianne Boes",

year = "2015",

month = feb,

language = "English",

volume = "21",

pages = "S240--S240",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

publisher = "Elsevier",

number = "2",

note = "BMT Tandem Meetings ; Conference date: 11-02-2015 Through 15-02-2015",

}

TY - JOUR

T1 - Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity

AU - Nierkens, Stefan

AU - Spel, Lotte

AU - van der Steen, Dirk

AU - Blokland, Nina

AU - Heemskerk, Mirjam

AU - Boelens, Jaap

AU - Boes, Marianne

PY - 2015/2

Y1 - 2015/2

N2 - Neuroblastoma is the most common solid tumor in pediatric patients, with a clear unmet need as survival rates are <20% for stage IV disease. As adjuvant immunotherapy is considered to have additional anti-tumor activity we aim to increase cytotoxic T lymphocyte (CTL)-mediated immune surveillance in neuroblastoma patients by administration of a dendritic cell-based vaccine. Neuroblastoma has developed mechanisms to circumvent CTL recognition; therefore it is our aim to find clinical strategies to make neuroblastoma susceptible for CTL killing

AB - Neuroblastoma is the most common solid tumor in pediatric patients, with a clear unmet need as survival rates are <20% for stage IV disease. As adjuvant immunotherapy is considered to have additional anti-tumor activity we aim to increase cytotoxic T lymphocyte (CTL)-mediated immune surveillance in neuroblastoma patients by administration of a dendritic cell-based vaccine. Neuroblastoma has developed mechanisms to circumvent CTL recognition; therefore it is our aim to find clinical strategies to make neuroblastoma susceptible for CTL killing

M3 - Meeting Abstract

SN - 1083-8791

VL - 21

SP - S240-S240

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 2

T2 - BMT Tandem Meetings

Y2 - 11 February 2015 through 15 February 2015

ER -

Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity

Abstract

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