Updates in Cryotherapy for Barrett's Esophagus

Charlotte N. Frederiks; Marcia Irene Canto; Bas L.A.M. Weusten

doi:10.1016/j.giec.2020.09.005

Updates in Cryotherapy for Barrett's Esophagus

Charlotte N. Frederiks, Marcia Irene Canto, Bas L.A.M. Weusten^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is cryospray ablation, which involves repetitive applications of liquid nitrogen. The second system, cryoballoon ablation, freezes the esophageal mucosa with liquid nitrous oxide using a compliant balloon. To date, studies have shown that cryotherapy is an effective and safe method for eradicating Barrett's esophagus; however, larger prospective series with longer follow-up are warranted to determine the clinical utility of cryotherapy in the treatment of Barrett's esophagus.

Original language	English
Pages (from-to)	155-170
Number of pages	16
Journal	Gastrointestinal Endoscopy Clinics of North America
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.giec.2020.09.005 https://doi.org/10.1016/j.giec.2020.09.005
Publication status	Published - Jan 2021

Keywords

Ablation therapy
Barrett's dysplasia
Barrett's esophagus
Barrett's neoplasia
Cryoablation
Cryotherapy

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title = "Updates in Cryotherapy for Barrett's Esophagus",

abstract = "Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is cryospray ablation, which involves repetitive applications of liquid nitrogen. The second system, cryoballoon ablation, freezes the esophageal mucosa with liquid nitrous oxide using a compliant balloon. To date, studies have shown that cryotherapy is an effective and safe method for eradicating Barrett's esophagus; however, larger prospective series with longer follow-up are warranted to determine the clinical utility of cryotherapy in the treatment of Barrett's esophagus.",

keywords = "Ablation therapy, Barrett's dysplasia, Barrett's esophagus, Barrett's neoplasia, Cryoablation, Cryotherapy",

author = "Frederiks, {Charlotte N.} and Canto, {Marcia Irene} and Weusten, {Bas L.A.M.}",

note = "Funding Information: For C.N. Frederiks no conflict of interest was declared. M.I. Canto has received research grants for IRB-approved studies from Pentax Medical Corporation (America). B.L.A.M. Weusten has received financial support for IRB-approved studies from Pentax Medical Corporation (America). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

doi = "10.1016/j.giec.2020.09.005",

language = "English",

volume = "31",

pages = "155--170",

journal = "Gastrointestinal Endoscopy Clinics of North America",

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AU - Frederiks, Charlotte N.

AU - Canto, Marcia Irene

AU - Weusten, Bas L.A.M.

N1 - Funding Information: For C.N. Frederiks no conflict of interest was declared. M.I. Canto has received research grants for IRB-approved studies from Pentax Medical Corporation (America). B.L.A.M. Weusten has received financial support for IRB-approved studies from Pentax Medical Corporation (America). Publisher Copyright: © 2020 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is cryospray ablation, which involves repetitive applications of liquid nitrogen. The second system, cryoballoon ablation, freezes the esophageal mucosa with liquid nitrous oxide using a compliant balloon. To date, studies have shown that cryotherapy is an effective and safe method for eradicating Barrett's esophagus; however, larger prospective series with longer follow-up are warranted to determine the clinical utility of cryotherapy in the treatment of Barrett's esophagus.

AB - Cryotherapy is an ablation modality relying on freeze-thaw cycles to promote cell death through intracellular ice crystal formation, ischemia, and apoptosis. Currently, 2 different cryotherapy systems are available for esophageal use. The first is cryospray ablation, which involves repetitive applications of liquid nitrogen. The second system, cryoballoon ablation, freezes the esophageal mucosa with liquid nitrous oxide using a compliant balloon. To date, studies have shown that cryotherapy is an effective and safe method for eradicating Barrett's esophagus; however, larger prospective series with longer follow-up are warranted to determine the clinical utility of cryotherapy in the treatment of Barrett's esophagus.

KW - Ablation therapy

KW - Barrett's dysplasia

KW - Barrett's esophagus

KW - Barrett's neoplasia

KW - Cryoablation

KW - Cryotherapy

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U2 - 10.1016/j.giec.2020.09.005

DO - 10.1016/j.giec.2020.09.005

M3 - Review article

C2 - 33213793

AN - SCOPUS:85096219474

SN - 1052-5157

VL - 31

SP - 155

EP - 170

JO - Gastrointestinal Endoscopy Clinics of North America

JF - Gastrointestinal Endoscopy Clinics of North America

IS - 1

ER -

Updates in Cryotherapy for Barrett's Esophagus

Abstract

Keywords

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