Update on research and clinical translation on specific clinical areas from biology to bedside: Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis

Jorg van Loosdregt, Femke van Wijk, Berent Prakken, Bas Vastert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

In the past decades, we have gained important insights into the mechanisms of disease and therapy underlying chronic inflammation in juvenile idiopathic arthritis (JIA). These insights have resulted in several game-changing therapeutic modalities for many patients. However, additional progress still has to be made with regard to efficacy, cost reduction, minimization of side effects, and dose-tapering and stop strategies of maintenance drugs. Moreover, to really transform the current therapeutic strategies into personalized medicine, we need validated biomarkers to translate increased insights into clinical practice. In this article, we describe recent developments in JIA research and outline how clinical innovations need to go hand in hand with basic discoveries to really effect care for patients. Facilitating the transition from bench to bedside is crucial for addressing the major current challenges in JIA management. When successful, it will set new standards for a safe, targeted, and personalized medicine in JIA.

Original languageEnglish
Pages (from-to)460-475
Number of pages16
JournalBest Practice and Research: Clinical Rheumatology
Volume31
Issue number4
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • Arthritis, Juvenile/drug therapy
  • Biology
  • Biomarkers
  • Child
  • Humans
  • Point-of-Care Systems
  • Precision Medicine
  • Translational Research, Biomedical

Fingerprint

Dive into the research topics of 'Update on research and clinical translation on specific clinical areas from biology to bedside: Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis'. Together they form a unique fingerprint.

Cite this