Update on Neuroendocrine Carcinomas of the Larynx

Carolina Strosberg; Alfio Ferlito; Asterios Triantafyllou; Douglas R Gnepp; Justin A Bishop; Henrik Hellquist; Primoz Strojan; Stefan M Willems; Göran Stenman; Alessandra Rinaldo; Juan C Hernandez-Prera

doi:10.1093/ajcp/aqz106

Update on Neuroendocrine Carcinomas of the Larynx

Carolina Strosberg, Alfio Ferlito, Asterios Triantafyllou, Douglas R Gnepp, Justin A Bishop, Henrik Hellquist, Primoz Strojan, Stefan M Willems, Göran Stenman, Alessandra Rinaldo, Juan C Hernandez-Prera

Research output: Contribution to journal › Review article › peer-review

Abstract

OBJECTIVES: Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities.

METHODS: A review of the literature was performed to comprehensively understand the classification and diagnosis of these tumors.

RESULTS: We review the past and present classification systems, with emphasis to the latest 2017 World Health Organization Classification of Head and Neck Tumors. We highlight salient clinicopathologic features and discuss the presumptive etiologic role of human papilloma virus. We share a practical algorithmic approach to the diagnosis of suspected neuroendocrine neoplasms of the larynx including a novel marker for neuroendocrine differentiation, insulinoma-associated protein 1.

CONCLUSIONS: Accurate diagnosis and grading of laryngeal neuroendocrine carcinomas is critical for prognostication and therapeutic decision making. The use of an algorithm is instrumental in assuring the exclusion of mimickers.

Original language	English
Pages (from-to)	686-700
Number of pages	15
Journal	American journal of clinical pathology
Volume	152
Issue number	6
Early online date	15 Aug 2019
DOIs	https://doi.org/10.1093/ajcp/aqz106
Publication status	Published - Dec 2019

Keywords

Human papillomavirus (HPV)
INSM1
Larynx
Neuroendocrine carcinoma
Neuroendocrine differentiation

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10.1093/ajcp/aqz106

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@article{83f0ef10da6c450cb179a8881682b3de,

title = "Update on Neuroendocrine Carcinomas of the Larynx",

abstract = "OBJECTIVES: Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities.METHODS: A review of the literature was performed to comprehensively understand the classification and diagnosis of these tumors.RESULTS: We review the past and present classification systems, with emphasis to the latest 2017 World Health Organization Classification of Head and Neck Tumors. We highlight salient clinicopathologic features and discuss the presumptive etiologic role of human papilloma virus. We share a practical algorithmic approach to the diagnosis of suspected neuroendocrine neoplasms of the larynx including a novel marker for neuroendocrine differentiation, insulinoma-associated protein 1.CONCLUSIONS: Accurate diagnosis and grading of laryngeal neuroendocrine carcinomas is critical for prognostication and therapeutic decision making. The use of an algorithm is instrumental in assuring the exclusion of mimickers.",

keywords = "Human papillomavirus (HPV), INSM1, Larynx, Neuroendocrine carcinoma, Neuroendocrine differentiation",

author = "Carolina Strosberg and Alfio Ferlito and Asterios Triantafyllou and Gnepp, {Douglas R} and Bishop, {Justin A} and Henrik Hellquist and Primoz Strojan and Willems, {Stefan M} and G{\"o}ran Stenman and Alessandra Rinaldo and Hernandez-Prera, {Juan C}",

year = "2019",

month = dec,

doi = "10.1093/ajcp/aqz106",

language = "English",

volume = "152",

pages = "686--700",

journal = "American journal of clinical pathology",

issn = "0002-9173",

publisher = "American Society of Clinical Pathologists",

number = "6",

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TY - JOUR

T1 - Update on Neuroendocrine Carcinomas of the Larynx

AU - Strosberg, Carolina

AU - Ferlito, Alfio

AU - Triantafyllou, Asterios

AU - Gnepp, Douglas R

AU - Bishop, Justin A

AU - Hellquist, Henrik

AU - Strojan, Primoz

AU - Willems, Stefan M

AU - Stenman, Göran

AU - Rinaldo, Alessandra

AU - Hernandez-Prera, Juan C

PY - 2019/12

Y1 - 2019/12

N2 - OBJECTIVES: Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities.METHODS: A review of the literature was performed to comprehensively understand the classification and diagnosis of these tumors.RESULTS: We review the past and present classification systems, with emphasis to the latest 2017 World Health Organization Classification of Head and Neck Tumors. We highlight salient clinicopathologic features and discuss the presumptive etiologic role of human papilloma virus. We share a practical algorithmic approach to the diagnosis of suspected neuroendocrine neoplasms of the larynx including a novel marker for neuroendocrine differentiation, insulinoma-associated protein 1.CONCLUSIONS: Accurate diagnosis and grading of laryngeal neuroendocrine carcinomas is critical for prognostication and therapeutic decision making. The use of an algorithm is instrumental in assuring the exclusion of mimickers.

AB - OBJECTIVES: Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities.METHODS: A review of the literature was performed to comprehensively understand the classification and diagnosis of these tumors.RESULTS: We review the past and present classification systems, with emphasis to the latest 2017 World Health Organization Classification of Head and Neck Tumors. We highlight salient clinicopathologic features and discuss the presumptive etiologic role of human papilloma virus. We share a practical algorithmic approach to the diagnosis of suspected neuroendocrine neoplasms of the larynx including a novel marker for neuroendocrine differentiation, insulinoma-associated protein 1.CONCLUSIONS: Accurate diagnosis and grading of laryngeal neuroendocrine carcinomas is critical for prognostication and therapeutic decision making. The use of an algorithm is instrumental in assuring the exclusion of mimickers.

KW - Human papillomavirus (HPV)

KW - INSM1

KW - Larynx

KW - Neuroendocrine carcinoma

KW - Neuroendocrine differentiation

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U2 - 10.1093/ajcp/aqz106

DO - 10.1093/ajcp/aqz106

M3 - Review article

C2 - 31415081

SN - 0002-9173

VL - 152

SP - 686

EP - 700

JO - American journal of clinical pathology

JF - American journal of clinical pathology

IS - 6

ER -

Update on Neuroendocrine Carcinomas of the Larynx

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Keywords

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