TY - JOUR
T1 - Unusual site of pseudomyxoma peritonei recurrence after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
T2 - a case report of intraluminal disease manifestation in the small bowel
AU - Rauwerdink, Paulien
AU - Brosens, Lodewijk A.A.
AU - van Diepen, Karin K.
AU - Ghedri, Okan N.
AU - Kranenburg, Onno
AU - Boerma, Djamila
AU - Witkamp, Arjen J.
AU - van Grevenstein, Helma M.U.
N1 - © 2022. The Author(s).
PY - 2022/5/10
Y1 - 2022/5/10
N2 - Background: Pseudomyxoma peritonei (PMP) is an uncommon clinical condition characterized by the presence of mucinous ascites, mainly induced by perforated appendiceal mucinous neoplasms (AMN). The peritoneal surface of the small bowel is usually spared from disease manifestation due to peristaltic movements. Mucinous tumours can disseminate as PMP on the entire peritoneum, but are rarely intraluminal. For the first time in literature, we report a case of intraluminal PMP involving the ileum. Case presentation: A 75-year-old male was treated for perforated AMN and disseminated PMP with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. During follow-up, the patient developed intraperitoneal recurrence together with intraluminal depositions in the ileum, both disease manifestations with identical KRAS and SMAD4 mutations. Hereafter, the patient was treated with palliative care. Conclusion: This case illustrates the variation in the biological and clinical behaviour of this rare disease. Clinicians should be aware of unusual tumour distribution patterns of PMP, including the presence of mucinous tumour within the small bowel.
AB - Background: Pseudomyxoma peritonei (PMP) is an uncommon clinical condition characterized by the presence of mucinous ascites, mainly induced by perforated appendiceal mucinous neoplasms (AMN). The peritoneal surface of the small bowel is usually spared from disease manifestation due to peristaltic movements. Mucinous tumours can disseminate as PMP on the entire peritoneum, but are rarely intraluminal. For the first time in literature, we report a case of intraluminal PMP involving the ileum. Case presentation: A 75-year-old male was treated for perforated AMN and disseminated PMP with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. During follow-up, the patient developed intraperitoneal recurrence together with intraluminal depositions in the ileum, both disease manifestations with identical KRAS and SMAD4 mutations. Hereafter, the patient was treated with palliative care. Conclusion: This case illustrates the variation in the biological and clinical behaviour of this rare disease. Clinicians should be aware of unusual tumour distribution patterns of PMP, including the presence of mucinous tumour within the small bowel.
KW - CRS-HIPEC
KW - High-grade appendiceal mucinous neoplasm
KW - Pseudomyxoma peritonei
KW - Recurrence
KW - SMAD4
KW - Small bowel
KW - Peritoneal Neoplasms/pathology
KW - Pseudomyxoma Peritonei/pathology
KW - Humans
KW - Male
KW - Hyperthermia, Induced/adverse effects
KW - Appendiceal Neoplasms/pathology
KW - Hyperthermic Intraperitoneal Chemotherapy
KW - Cytoreduction Surgical Procedures/adverse effects
KW - Aged
KW - Retrospective Studies
UR - http://www.scopus.com/inward/record.url?scp=85129724592&partnerID=8YFLogxK
U2 - 10.1186/s12957-022-02613-2
DO - 10.1186/s12957-022-02613-2
M3 - Article
C2 - 35538541
AN - SCOPUS:85129724592
SN - 1477-7819
VL - 20
SP - 1
EP - 7
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
IS - 1
M1 - 147
ER -