Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

Paul D Kruithof; Sergey Lunev; Sheila P Aguilar Lozano; Fernando de Assis Batista; Zayana M Al-Dahmani; Jaap A Joles; Amalia M Dolga; Matthew R Groves; Harry van Goor

doi:10.1016/j.bbadis.2020.165716

Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

Paul D Kruithof
, Sergey Lunev
, Sheila P Aguilar Lozano
, Fernando de Assis Batista
, Zayana M Al-Dahmani
, Jaap A Joles
, Amalia M Dolga
, Matthew R Groves
, Harry van Goor

Research output: Contribution to journal › Review article › peer-review

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Abstract

Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

Original language	English
Article number	165716
Journal	Biochimica et Biophysica Acta. Molecular Basis of Disease
Volume	1866
Issue number	6
DOIs	https://doi.org/10.1016/j.bbadis.2020.165716
Publication status	Published - 1 Jun 2020

Keywords

Sulfurtransferase
TST
Rhodanese
Diabetes
Obesity
Antioxidant systems

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10.1016/j.bbadis.2020.165716

1-s2.0-S0925443920300612-mainFinal published version, 892 KB

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title = "Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases",

abstract = "Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.",

keywords = "Sulfurtransferase, TST, Rhodanese, Diabetes, Obesity, Antioxidant systems",

author = "Kruithof, \{Paul D\} and Sergey Lunev and \{Aguilar Lozano\}, \{Sheila P\} and \{de Assis Batista\}, Fernando and Al-Dahmani, \{Zayana M\} and Joles, \{Jaap A\} and Dolga, \{Amalia M\} and Groves, \{Matthew R\} and \{van Goor\}, Harry",

note = "Funding Information: This research was supported by a grant from the Dutch kidney Foundation (\#17O16) . Z. M. Al-Dahmani was supported by the Islamic Development Bank . Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = jun,

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doi = "10.1016/j.bbadis.2020.165716",

language = "English",

volume = "1866",

journal = "Biochimica et Biophysica Acta. Molecular Basis of Disease",

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T1 - Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

AU - Kruithof, Paul D

AU - Lunev, Sergey

AU - Aguilar Lozano, Sheila P

AU - de Assis Batista, Fernando

AU - Al-Dahmani, Zayana M

AU - Joles, Jaap A

AU - Dolga, Amalia M

AU - Groves, Matthew R

AU - van Goor, Harry

N1 - Funding Information: This research was supported by a grant from the Dutch kidney Foundation (#17O16) . Z. M. Al-Dahmani was supported by the Islamic Development Bank . Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

AB - Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.

KW - Sulfurtransferase

KW - TST

KW - Rhodanese

KW - Diabetes

KW - Obesity

KW - Antioxidant systems

UR - https://www.scopus.com/pages/publications/85079532213

U2 - 10.1016/j.bbadis.2020.165716

DO - 10.1016/j.bbadis.2020.165716

M3 - Review article

C2 - 32061776

SN - 0925-4439

VL - 1866

JO - Biochimica et Biophysica Acta. Molecular Basis of Disease

JF - Biochimica et Biophysica Acta. Molecular Basis of Disease

IS - 6

M1 - 165716

ER -

Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases

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