Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study

Carleen M E M Adriaansens; Klijs J de Koning; Remco de Bree; Jan Willem Dankbaar; Gerben E Breimer; Robert J J van Es; Rob Noorlag

doi:10.1002/hed.27281

Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study

Carleen M E M Adriaansens^*
, Klijs J de Koning
, Remco de Bree
, Jan Willem Dankbaar
, Gerben E Breimer
, Robert J J van Es
, Rob Noorlag

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Image-guided surgery could help obtain clear (≥5.0 mm) resection margins. This feasibility study investigated ultrasound-guided resection accuracy of buccal mucosa squamous cell carcinoma (BMSCC).

METHODS: MRI and ultrasound measurements of tumor thickness were compared to histology in 13 BMSCC-patients. Ultrasound measured margins (at five locations) on the specimen were compared to the corresponding histological margins.

RESULTS: Accuracy of in- and ex-vivo ultrasound (mean deviation from histology: 1.6 mm) for measuring tumor thickness was comparable to MRI (mean deviation from histology: 2.6 mm). The sensitivity to detect clear margins using ex-vivo ultrasound was low (48%). If an ex-vivo ultrasound cutoff of ≥7.5 mm would be used, the sensitivity would increase to 86%.

CONCLUSIONS: Ultrasound-guided resection of BMSCC's is feasible. In- and ex-vivo ultrasound measure tumor thickness in BMSCC accurately. We recommend ≥7.5 mm resection margins on ex-vivo ultrasound to obtain histological clear margins. Additional research is required to establish the effect of 7.5 mm ultrasound cutoff.

Original language	English
Pages (from-to)	647-657
Number of pages	11
Journal	Head & neck
Volume	45
Issue number	3
Early online date	18 Dec 2022
DOIs	https://doi.org/10.1002/hed.27281
Publication status	Published - Mar 2023

Keywords

buccal mucosa squamous cell carcinoma
image-guided surgery
oral cancer
resection margins
ultrasonography

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10.1002/hed.27281Licence: CC BY-NC

Head Neck - 2022 - Adriaansens - Ultrasound‐guided resection for squamous cell carcinoma of the buccal mucosa AFinal published version, 1.53 MBLicence: CC BY-NC

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@article{9f83e8db5486457fa67ede5164104db2,

title = "Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study",

abstract = "BACKGROUND: Image-guided surgery could help obtain clear (≥5.0 mm) resection margins. This feasibility study investigated ultrasound-guided resection accuracy of buccal mucosa squamous cell carcinoma (BMSCC).METHODS: MRI and ultrasound measurements of tumor thickness were compared to histology in 13 BMSCC-patients. Ultrasound measured margins (at five locations) on the specimen were compared to the corresponding histological margins.RESULTS: Accuracy of in- and ex-vivo ultrasound (mean deviation from histology: 1.6 mm) for measuring tumor thickness was comparable to MRI (mean deviation from histology: 2.6 mm). The sensitivity to detect clear margins using ex-vivo ultrasound was low (48\%). If an ex-vivo ultrasound cutoff of ≥7.5 mm would be used, the sensitivity would increase to 86\%.CONCLUSIONS: Ultrasound-guided resection of BMSCC's is feasible. In- and ex-vivo ultrasound measure tumor thickness in BMSCC accurately. We recommend ≥7.5 mm resection margins on ex-vivo ultrasound to obtain histological clear margins. Additional research is required to establish the effect of 7.5 mm ultrasound cutoff.",

keywords = "buccal mucosa squamous cell carcinoma, image-guided surgery, oral cancer, resection margins, ultrasonography",

author = "Adriaansens, \{Carleen M E M\} and \{de Koning\}, \{Klijs J\} and \{de Bree\}, Remco and Dankbaar, \{Jan Willem\} and Breimer, \{Gerben E\} and \{van Es\}, \{Robert J J\} and Rob Noorlag",

note = "Funding Information: KWF Kankerbestrijding, Grant/Award Number: 13577 Publisher Copyright: {\textcopyright} 2022 The Authors. Head \& Neck published by Wiley Periodicals LLC.",

year = "2023",

month = mar,

doi = "10.1002/hed.27281",

language = "English",

volume = "45",

pages = "647--657",

journal = "Head \& neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "3",

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TY - JOUR

T1 - Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa

T2 - A feasibility study

AU - Adriaansens, Carleen M E M

AU - de Koning, Klijs J

AU - de Bree, Remco

AU - Dankbaar, Jan Willem

AU - Breimer, Gerben E

AU - van Es, Robert J J

AU - Noorlag, Rob

PY - 2023/3

Y1 - 2023/3

N2 - BACKGROUND: Image-guided surgery could help obtain clear (≥5.0 mm) resection margins. This feasibility study investigated ultrasound-guided resection accuracy of buccal mucosa squamous cell carcinoma (BMSCC).METHODS: MRI and ultrasound measurements of tumor thickness were compared to histology in 13 BMSCC-patients. Ultrasound measured margins (at five locations) on the specimen were compared to the corresponding histological margins.RESULTS: Accuracy of in- and ex-vivo ultrasound (mean deviation from histology: 1.6 mm) for measuring tumor thickness was comparable to MRI (mean deviation from histology: 2.6 mm). The sensitivity to detect clear margins using ex-vivo ultrasound was low (48%). If an ex-vivo ultrasound cutoff of ≥7.5 mm would be used, the sensitivity would increase to 86%.CONCLUSIONS: Ultrasound-guided resection of BMSCC's is feasible. In- and ex-vivo ultrasound measure tumor thickness in BMSCC accurately. We recommend ≥7.5 mm resection margins on ex-vivo ultrasound to obtain histological clear margins. Additional research is required to establish the effect of 7.5 mm ultrasound cutoff.

AB - BACKGROUND: Image-guided surgery could help obtain clear (≥5.0 mm) resection margins. This feasibility study investigated ultrasound-guided resection accuracy of buccal mucosa squamous cell carcinoma (BMSCC).METHODS: MRI and ultrasound measurements of tumor thickness were compared to histology in 13 BMSCC-patients. Ultrasound measured margins (at five locations) on the specimen were compared to the corresponding histological margins.RESULTS: Accuracy of in- and ex-vivo ultrasound (mean deviation from histology: 1.6 mm) for measuring tumor thickness was comparable to MRI (mean deviation from histology: 2.6 mm). The sensitivity to detect clear margins using ex-vivo ultrasound was low (48%). If an ex-vivo ultrasound cutoff of ≥7.5 mm would be used, the sensitivity would increase to 86%.CONCLUSIONS: Ultrasound-guided resection of BMSCC's is feasible. In- and ex-vivo ultrasound measure tumor thickness in BMSCC accurately. We recommend ≥7.5 mm resection margins on ex-vivo ultrasound to obtain histological clear margins. Additional research is required to establish the effect of 7.5 mm ultrasound cutoff.

KW - buccal mucosa squamous cell carcinoma

KW - image-guided surgery

KW - oral cancer

KW - resection margins

KW - ultrasonography

UR - https://www.scopus.com/pages/publications/85144166159

U2 - 10.1002/hed.27281

DO - 10.1002/hed.27281

M3 - Article

C2 - 36528853

SN - 1043-3074

VL - 45

SP - 647

EP - 657

JO - Head & neck

JF - Head & neck

IS - 3

ER -

Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study

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