Uitbraak van vancomycineresistente Enterococcus faecium op een afdeling nefrologie

Translated title of the contribution: An outbreak of vancomycin-resistant Enterococcus faecium in a nephrology ward

L F van der Steen, M. J.M. Bonten*, E. van Kregten, J. J.C. Harssema-Poot, R. Willems, C. A. Gaillard

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)


In April 2000, an outbreak of vancomycin-resistant Enterococcus faecium (VRE) was discovered in an internal medicine/nephrology and dialysis ward of the Eemland Hospital, Amersfoort, the Netherlands. Although enterococci are considered relatively non-virulent, VRE are resistant to almost all commercially available antibiotics. Surveillance cultures were obtained from all patients at the ward, all patients visiting the dialysis ward and the environment of patients. VRE were determined and clustering of strains was analysed using molecular genotyping. In all, 12 patients were colonized with the outbreak strain. Transmission of VRE usually occurs via the hands of health care workers. The ward was closed for new admissions, patients were divided in cohorts of colonized and non-colonized patients, and rooms were disinfected after patient discharge. Infection control measures (such as handwashing and use of gloves and gowns) were enforced and prescriptions of vancomycin and cephalosporins were reduced. With these measures the outbreak could be controlled. Epidemiological analysis demonstrated that earlier admission and previous use of ciprofloxacin, amoxicillin and amoxicillin-clavulanic acid were risk factors for colonization. A nearby hospital was a possible source of this outbreak.

Translated title of the contributionAn outbreak of vancomycin-resistant Enterococcus faecium in a nephrology ward
Original languageDutch
Pages (from-to)2568-2572
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Issue number53
Publication statusPublished - 30 Dec 2000


  • Aged
  • Disease Outbreaks
  • Enterococcus faecium
  • Female
  • Genotype
  • Gram-Positive Bacterial Infections
  • Hemodialysis Units, Hospital
  • Humans
  • Incidence
  • Infection Control
  • Infectious Disease Transmission, Professional-to-Patient
  • Male
  • Middle Aged
  • Netherlands
  • Risk Factors
  • Vancomycin Resistance
  • English Abstract
  • Journal Article


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