TY - JOUR
T1 - Two cosmoses, one universe
T2 - a narrative review exploring the gut microbiome's role in the effect of urban risk factors on vascular ageing
AU - Bridge, Lara Anne
AU - Hernández Vargas, Juliana Alexandra
AU - Trujillo-Cáceres, Silvia Juliana
AU - Beigrezaei, Sara
AU - Chatelan, Angeline
AU - Salehi-Abargouei, Amin
AU - Muka, Taulant
AU - Uriza-Pinzón, Julieth Pilar
AU - Raeisi-Dehkordi, Hamidreza
AU - Franco, Oscar H
AU - Grompone, Gianfranco
AU - Artola Arita, Vicente
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/6/1
Y1 - 2024/6/1
N2 - In the face of rising global urbanisation, understanding how the associated environment and lifestyle impact public health is a cornerstone for prevention, research, and clinical practice. Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with urban risk factors contributing greatly to its burden. The current narrative review adopts an exposome approach to explore the effect of urban-associated physical-chemical factors (such as air pollution) and lifestyle on cardiovascular health and ageing. In addition, we provide new insights into how these urban-related factors alter the gut microbiome, which has been associated with an increased risk of cardiovascular disease. We focus on vascular ageing, before disease onset, to promote preventative research and practice. We also discuss how urban ecosystems and social factors may interact with these pathways and provide suggestions for future research, precision prevention and management of vascular ageing. Most importantly, future research and decision-making would benefit from adopting an exposome approach and acknowledging the diverse and boundless universe of the microbiome.
AB - In the face of rising global urbanisation, understanding how the associated environment and lifestyle impact public health is a cornerstone for prevention, research, and clinical practice. Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with urban risk factors contributing greatly to its burden. The current narrative review adopts an exposome approach to explore the effect of urban-associated physical-chemical factors (such as air pollution) and lifestyle on cardiovascular health and ageing. In addition, we provide new insights into how these urban-related factors alter the gut microbiome, which has been associated with an increased risk of cardiovascular disease. We focus on vascular ageing, before disease onset, to promote preventative research and practice. We also discuss how urban ecosystems and social factors may interact with these pathways and provide suggestions for future research, precision prevention and management of vascular ageing. Most importantly, future research and decision-making would benefit from adopting an exposome approach and acknowledging the diverse and boundless universe of the microbiome.
KW - Ambient air pollution
KW - Cardiovascular health
KW - Diet
KW - Exposome
KW - Gut microbiome
KW - Lifestyles
KW - Particulate matter
KW - Physical activity
KW - Urbanisation
KW - Vascular ageing
UR - http://www.scopus.com/inward/record.url?scp=85188162197&partnerID=8YFLogxK
U2 - 10.1016/j.maturitas.2024.107951
DO - 10.1016/j.maturitas.2024.107951
M3 - Review article
C2 - 38471294
SN - 0378-5122
VL - 184
JO - Maturitas
JF - Maturitas
M1 - 107951
ER -