Tumorigenicity of the miR-17-92 cluster distilled

Gijs Van Haaften; Reuven Agami

doi:10.1101/gad.1887110

Tumorigenicity of the miR-17-92 cluster distilled

Gijs Van Haaften, Reuven Agami^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

The miR-17-92 gene cluster, with its six different mature microRNAs (miRNAs), has an established oncogenic function. However, the oncogenic contribution of each individual miRNA in the cluster has not been assigned. Two studies published in the December 15, 2009, issue of Genes & Development by Mu and colleagues (pp. 2806-2811) and Olive and colleagues (pp. 2839-2849) dissected the miR-17-92 cluster to its individual miRNA components and identified their relative contributions to oncogenic transformation in mouse model systems.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Genes and Development
Volume	24
Issue number	1
DOIs	https://doi.org/10.1101/gad.1887110
Publication status	Published - 1 Jan 2010

Keywords

Apoptosis
Cancer
MicroRNAs
Mir-17-92
Mir-19
Myc

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10.1101/gad.1887110

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KW - Cancer

KW - MicroRNAs

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KW - Mir-19

KW - Myc

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Tumorigenicity of the miR-17-92 cluster distilled

Abstract

Keywords

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