Tumor necrosis factor induces von Willebrand factor release in healthy humans

T. Van der Poll; S. J.H. Van Deventer; G. Pasterkamp; J. A. Van Mourik; H. R. Buller; J. W. Ten Cate

Tumor necrosis factor induces von Willebrand factor release in healthy humans

T. Van der Poll^*, S. J.H. Van Deventer, G. Pasterkamp, J. A. Van Mourik, H. R. Buller, J. W. Ten Cate

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Tumor necrosis factor (TNF) is an important mediator of the host responses to systemic infection. To investigate the effect of TNF on the release of von Willebrand factor (vWF) into the circulation, we performed a controlled study in six healthy men, sequentially measuring the plasma concentrations of vWF antigen after a bolus intravenous injection of recombinant human TNF (50 μg/m²). TNF induced a marked increase in vWF antigen plasma levels, becoming significant after 45 min and peaking after 4h (percentage increase from base line: 351 ± 46; p < 0.0001, TNF versus saline). The multimeric organization of circulating vWF was not affected by TNF. We conclude that TNF may be an early mediator of increased vWF secretion in systemic infection.

Original language	English
Pages (from-to)	623-626
Number of pages	4
Journal	Thrombosis and Haemostasis
Volume	67
Issue number	6
Publication status	Published - 1 Jan 1992

Cite this

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title = "Tumor necrosis factor induces von Willebrand factor release in healthy humans",

abstract = "Tumor necrosis factor (TNF) is an important mediator of the host responses to systemic infection. To investigate the effect of TNF on the release of von Willebrand factor (vWF) into the circulation, we performed a controlled study in six healthy men, sequentially measuring the plasma concentrations of vWF antigen after a bolus intravenous injection of recombinant human TNF (50 μg/m2). TNF induced a marked increase in vWF antigen plasma levels, becoming significant after 45 min and peaking after 4h (percentage increase from base line: 351 ± 46; p < 0.0001, TNF versus saline). The multimeric organization of circulating vWF was not affected by TNF. We conclude that TNF may be an early mediator of increased vWF secretion in systemic infection.",

author = "{Van der Poll}, T. and {Van Deventer}, {S. J.H.} and G. Pasterkamp and {Van Mourik}, {J. A.} and Buller, {H. R.} and {Ten Cate}, {J. W.}",

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AU - Van der Poll, T.

AU - Van Deventer, S. J.H.

AU - Pasterkamp, G.

AU - Van Mourik, J. A.

AU - Buller, H. R.

AU - Ten Cate, J. W.

PY - 1992/1/1

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N2 - Tumor necrosis factor (TNF) is an important mediator of the host responses to systemic infection. To investigate the effect of TNF on the release of von Willebrand factor (vWF) into the circulation, we performed a controlled study in six healthy men, sequentially measuring the plasma concentrations of vWF antigen after a bolus intravenous injection of recombinant human TNF (50 μg/m2). TNF induced a marked increase in vWF antigen plasma levels, becoming significant after 45 min and peaking after 4h (percentage increase from base line: 351 ± 46; p < 0.0001, TNF versus saline). The multimeric organization of circulating vWF was not affected by TNF. We conclude that TNF may be an early mediator of increased vWF secretion in systemic infection.

AB - Tumor necrosis factor (TNF) is an important mediator of the host responses to systemic infection. To investigate the effect of TNF on the release of von Willebrand factor (vWF) into the circulation, we performed a controlled study in six healthy men, sequentially measuring the plasma concentrations of vWF antigen after a bolus intravenous injection of recombinant human TNF (50 μg/m2). TNF induced a marked increase in vWF antigen plasma levels, becoming significant after 45 min and peaking after 4h (percentage increase from base line: 351 ± 46; p < 0.0001, TNF versus saline). The multimeric organization of circulating vWF was not affected by TNF. We conclude that TNF may be an early mediator of increased vWF secretion in systemic infection.

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AN - SCOPUS:0026690386

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JF - Thrombosis and Haemostasis

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Tumor necrosis factor induces von Willebrand factor release in healthy humans

Abstract

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