Tubuloreticular structures in different types of myositis: Implications for pathogenesis

Irene M. Bronner; Jessica E. Hoogendijk; Henk Veldman; Marja Ramkema; Marius A. Van Den Bergh Weerman; Annemieke J M Rozemuller; Marianne De Visser

doi:10.1080/01913120802209379

Tubuloreticular structures in different types of myositis: Implications for pathogenesis

Irene M. Bronner, Jessica E. Hoogendijk, Henk Veldman, Marja Ramkema, Marius A. Van Den Bergh Weerman, Annemieke J M Rozemuller, Marianne De Visser^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjogren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively. Copyright © Informa Healthcare USA, Inc.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Ultrastructural pathology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1080/01913120802209379
Publication status	Published - Aug 2008

Keywords

Adult
Aged
Arthritis, Rheumatoid
Biopsy
Capillaries
Dermatomyositis
Endothelium, Vascular
Female
Humans
Inclusion Bodies
Lupus Erythematosus, Discoid
Male
Microscopy, Electron, Transmission
Microtubules
Middle Aged
Mixed Connective Tissue Disease
Muscle, Skeletal
Scleroderma, Systemic
Sjogren's Syndrome
Journal Article
Research Support, Non-U.S. Gov't

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10.1080/01913120802209379

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title = "Tubuloreticular structures in different types of myositis: Implications for pathogenesis",

abstract = "In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjogren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively. Copyright {\textcopyright} Informa Healthcare USA, Inc.",

keywords = "Adult, Aged, Arthritis, Rheumatoid, Biopsy, Capillaries, Dermatomyositis, Endothelium, Vascular, Female, Humans, Inclusion Bodies, Lupus Erythematosus, Discoid, Male, Microscopy, Electron, Transmission, Microtubules, Middle Aged, Mixed Connective Tissue Disease, Muscle, Skeletal, Scleroderma, Systemic, Sjogren's Syndrome, Journal Article, Research Support, Non-U.S. Gov't",

author = "Bronner, {Irene M.} and Hoogendijk, {Jessica E.} and Henk Veldman and Marja Ramkema and {Van Den Bergh Weerman}, {Marius A.} and Rozemuller, {Annemieke J M} and {De Visser}, Marianne",

year = "2008",

month = aug,

doi = "10.1080/01913120802209379",

language = "English",

volume = "32",

pages = "123--126",

journal = "Ultrastructural pathology",

issn = "0191-3123",

publisher = "Informa Healthcare",

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T1 - Tubuloreticular structures in different types of myositis

T2 - Implications for pathogenesis

AU - Bronner, Irene M.

AU - Hoogendijk, Jessica E.

AU - Veldman, Henk

AU - Ramkema, Marja

AU - Van Den Bergh Weerman, Marius A.

AU - Rozemuller, Annemieke J M

AU - De Visser, Marianne

PY - 2008/8

Y1 - 2008/8

N2 - In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjogren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively. Copyright © Informa Healthcare USA, Inc.

AB - In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjogren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively. Copyright © Informa Healthcare USA, Inc.

KW - Adult

KW - Aged

KW - Arthritis, Rheumatoid

KW - Biopsy

KW - Capillaries

KW - Dermatomyositis

KW - Endothelium, Vascular

KW - Female

KW - Humans

KW - Inclusion Bodies

KW - Lupus Erythematosus, Discoid

KW - Male

KW - Microscopy, Electron, Transmission

KW - Microtubules

KW - Middle Aged

KW - Mixed Connective Tissue Disease

KW - Muscle, Skeletal

KW - Scleroderma, Systemic

KW - Sjogren's Syndrome

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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U2 - 10.1080/01913120802209379

DO - 10.1080/01913120802209379

M3 - Article

C2 - 18696397

SN - 0191-3123

VL - 32

SP - 123

EP - 126

JO - Ultrastructural pathology

JF - Ultrastructural pathology

IS - 4

ER -

Tubuloreticular structures in different types of myositis: Implications for pathogenesis

Abstract

Keywords

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