Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

P. B.B. Schol; C. Güzel; E. A.P. Steegers; R. R. De Krijger; T. M. Luider

doi:10.1016/j.preghy.2013.11.003

Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

P. B.B. Schol, C. Güzel, E. A.P. Steegers, R. R. De Krijger, T. M. Luider^*

^*Corresponding author for this work

Department of Pathology

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca²⁺-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ², p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	Pregnancy Hypertension
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.preghy.2013.11.003
Publication status	Published - 1 Jan 2014

Keywords

Calcyclin
Pre-eclampsia
S100A6
Trophoblast

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abstract = "The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca2+-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ2, p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .",

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AU - Schol, P. B.B.

AU - Güzel, C.

AU - Steegers, E. A.P.

AU - De Krijger, R. R.

AU - Luider, T. M.

PY - 2014/1/1

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AB - The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca2+-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n = 72) and non-hypertensive control patients (n = 66) (χ2, p = 0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy .

KW - Calcyclin

KW - Pre-eclampsia

KW - S100A6

KW - Trophoblast

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Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia

Abstract

Keywords

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