Treatment of patients with long-standing unexplained subfertility with in vitro fertilization

Peter F. Donderwinkel, Hester Van Der Vaart, Victorien M. Wolters, Arnold H. Simons, Gerard Kroon, Maas Jan Heineman

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)


Objective: To evaluate whether IVF is an effective treatment for long-standing unexplained subfertility.Design: Retrospective cohort study.Setting: Tertiary care infertility center in a university hospital.Patient(s): Two hundred two couples with unexplained subfertility of 2 years’ duration or more who attended the center for their first IVF attempt.Intervention(s): Couples were placed on a waiting list for IVF. They received no treatment until IVF was started.Main Outcome Measure(s): Pregnancy rate (PR) while on the waiting list and PR after IVF treatment.Result(s): Complete data sets were available for 131 couples. Seventeen of 131 women became pregnant while waiting for IVF treatment (PR 0.9% per exposure cycle), whereas 45 of 119 receiving IVF treatment became pregnant (PR 17% per IVF attempt).Conclusion(s): IVF treatment has substantial added value over waiting and is an efficient treatment for long-standing unexplained subfertility.

Original languageEnglish
Pages (from-to)334-337
Number of pages4
JournalFertility and Sterility
Issue number2
Publication statusPublished - 1 Jan 2000


  • IVF treatment
  • No treatment
  • Retrospective cohort study
  • Unexplained subfertility
  • Waiting list


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