Treatment of cytomegalovirus pneumonia after bone marrow transplantation with cytomegalovirus immunoglobulin combined with ganciclovir

L F Verdonck; G C de Gast; A W Dekker; R A de Weger; H J Schuurman; M Rozenberg-Arska

Treatment of cytomegalovirus pneumonia after bone marrow transplantation with cytomegalovirus immunoglobulin combined with ganciclovir

L F Verdonck, G C de Gast, A W Dekker, R A de Weger, H J Schuurman, M Rozenberg-Arska

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We studied the effect of cytomegalovirus immunoglobulin alone, or combined with ganciclovir, on the outcome of biopsy proven cytomegalovirus pneumonia after bone marrow transplantation. Treatment with cytomegalovirus immunoglobulin alone had no effect on the cytomegalovirus nor on clinical outcome. The combined treatment of cytomegalovirus immunoglobulin with ganciclovir suppressed the cytomegalovirus but all patients died because of ongoing pulmonary deterioration. These results may suggest that this combined treatment has limited value on the outcome of an established cytomegalovirus pneumonia after marrow transplantation.

Original language	English
Pages (from-to)	187-9
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	4
Issue number	2
Publication status	Published - 1989

Keywords

Acyclovir
Adult
Antiviral Agents
Bone Marrow Transplantation
Cytomegalovirus
Cytomegalovirus Infections
Drug Therapy, Combination
Female
Ganciclovir
Humans
Immunization, Passive
Immunoglobulins
Male
Middle Aged
Pneumonia, Viral
Postoperative Complications

Cite this

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title = "Treatment of cytomegalovirus pneumonia after bone marrow transplantation with cytomegalovirus immunoglobulin combined with ganciclovir",

abstract = "We studied the effect of cytomegalovirus immunoglobulin alone, or combined with ganciclovir, on the outcome of biopsy proven cytomegalovirus pneumonia after bone marrow transplantation. Treatment with cytomegalovirus immunoglobulin alone had no effect on the cytomegalovirus nor on clinical outcome. The combined treatment of cytomegalovirus immunoglobulin with ganciclovir suppressed the cytomegalovirus but all patients died because of ongoing pulmonary deterioration. These results may suggest that this combined treatment has limited value on the outcome of an established cytomegalovirus pneumonia after marrow transplantation.",

keywords = "Acyclovir, Adult, Antiviral Agents, Bone Marrow Transplantation, Cytomegalovirus, Cytomegalovirus Infections, Drug Therapy, Combination, Female, Ganciclovir, Humans, Immunization, Passive, Immunoglobulins, Male, Middle Aged, Pneumonia, Viral, Postoperative Complications",

author = "Verdonck, {L F} and {de Gast}, {G C} and Dekker, {A W} and {de Weger}, {R A} and Schuurman, {H J} and M Rozenberg-Arska",

year = "1989",

language = "English",

volume = "4",

pages = "187--9",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Springer Nature",

number = "2",

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TY - JOUR

T1 - Treatment of cytomegalovirus pneumonia after bone marrow transplantation with cytomegalovirus immunoglobulin combined with ganciclovir

AU - Verdonck, L F

AU - de Gast, G C

AU - Dekker, A W

AU - de Weger, R A

AU - Schuurman, H J

AU - Rozenberg-Arska, M

PY - 1989

Y1 - 1989

N2 - We studied the effect of cytomegalovirus immunoglobulin alone, or combined with ganciclovir, on the outcome of biopsy proven cytomegalovirus pneumonia after bone marrow transplantation. Treatment with cytomegalovirus immunoglobulin alone had no effect on the cytomegalovirus nor on clinical outcome. The combined treatment of cytomegalovirus immunoglobulin with ganciclovir suppressed the cytomegalovirus but all patients died because of ongoing pulmonary deterioration. These results may suggest that this combined treatment has limited value on the outcome of an established cytomegalovirus pneumonia after marrow transplantation.

AB - We studied the effect of cytomegalovirus immunoglobulin alone, or combined with ganciclovir, on the outcome of biopsy proven cytomegalovirus pneumonia after bone marrow transplantation. Treatment with cytomegalovirus immunoglobulin alone had no effect on the cytomegalovirus nor on clinical outcome. The combined treatment of cytomegalovirus immunoglobulin with ganciclovir suppressed the cytomegalovirus but all patients died because of ongoing pulmonary deterioration. These results may suggest that this combined treatment has limited value on the outcome of an established cytomegalovirus pneumonia after marrow transplantation.

KW - Acyclovir

KW - Adult

KW - Antiviral Agents

KW - Bone Marrow Transplantation

KW - Cytomegalovirus

KW - Cytomegalovirus Infections

KW - Drug Therapy, Combination

KW - Female

KW - Ganciclovir

KW - Humans

KW - Immunization, Passive

KW - Immunoglobulins

KW - Male

KW - Middle Aged

KW - Pneumonia, Viral

KW - Postoperative Complications

M3 - Article

C2 - 2539877

SN - 0268-3369

VL - 4

SP - 187

EP - 189

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 2

ER -

Treatment of cytomegalovirus pneumonia after bone marrow transplantation with cytomegalovirus immunoglobulin combined with ganciclovir

Abstract

Keywords

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