Treatment and outcome of neuroblastoma with intraspinal extension: A systematic review

Kathelijne Kraal*, Thomas Blom, Max van Noesel, Leontien Kremer, Huib Caron, Godelieve Tytgat, Heleen van der Pal

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension. More well-designed, prospective studies are needed to determine the optimal treatment strategy.

Original languageEnglish
Article numbere26451
JournalPediatric Blood and Cancer
Issue number8
Publication statusPublished - Aug 2017
Externally publishedYes


  • intraspinal extension
  • late effects
  • long-term health problems
  • neuroblastoma
  • spinal cord compression
  • systematic review


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