Transporting silence: Design of carriers for siRNA to angiogenic endothelium

Raymond M. Schiffelers*, Archibald J. Mixson, Aslam M. Ansari, Marcel H.A.M. Fens, Quingquan Tang, Qin Zhou, Jun Xu, Grietje Molema, Patrick Y. Lu, Puthupparampil V. Scaria, Gert Storm, Martin C. Woodle

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

The recently developed siRNA oligonucleotides are an attractive alternative to antisense as a therapeutic modality because of their robust, gene selective silencing of drug target protein expression. To achieve therapeutic success, however, several hurdles must be overcome including rapid clearance, nuclease degradation, and inefficient intracellular localization. In this presentation, we discuss design strategies for development of self-assembling nanoscale carriers for neovasculature targeted delivery of siRNA inhibiting tumor or ocular angiogenesis.

Original languageEnglish
Pages (from-to)5-14
Number of pages10
JournalJournal of Controlled Release
Volume109
Issue number1-3
DOIs
Publication statusPublished - 5 Dec 2005

Keywords

  • Angiogenesis
  • Drug targeting
  • RNA interference
  • siRNA

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