Translational applications of adult stem cell-derived organoids

Jarno Drost; Hans Clevers

doi:10.1242/dev.140566

Translational applications of adult stem cell-derived organoids

Jarno Drost
, Hans Clevers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

3 Downloads (Pure)

Abstract

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.

Original language	English
Pages (from-to)	968-975
Number of pages	8
Journal	Development (Cambridge, England)
Volume	144
Issue number	6
DOIs	https://doi.org/10.1242/dev.140566
Publication status	Published - 15 Mar 2017

Keywords

Adult stem cells
Cancer
Disease modelling
Organoids

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10.1242/dev.140566

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title = "Translational applications of adult stem cell-derived organoids",

abstract = "Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.",

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author = "Jarno Drost and Hans Clevers",

note = "Funding Information: We are grateful for support from The Netherlands Organization for Scientific Research [Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)- ZonMw] VENI grant to J.D. (91614138) and the Cancer Genomics.nl (NWO Gravitation) program to H.C. Publisher Copyright: {\textcopyright} 2017. Published by The Company of Biologists Ltd.",

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AU - Clevers, Hans

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N2 - Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.

AB - Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.

KW - Adult stem cells

KW - Cancer

KW - Disease modelling

KW - Organoids

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ER -

Translational applications of adult stem cell-derived organoids

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Keywords

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