Abstract
Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.
| Original language | English |
|---|---|
| Pages (from-to) | 968-975 |
| Number of pages | 8 |
| Journal | Development (Cambridge, England) |
| Volume | 144 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 15 Mar 2017 |
Keywords
- Adult stem cells
- Cancer
- Disease modelling
- Organoids