Translating cell biology in vitro to immunity in vivo

M Boes; HL Ploegh

doi:10.1038/nature02762

Translating cell biology in vitro to immunity in vivo

M Boes^*, HL Ploegh

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The elimination of pathogens and pathogen-infected cells initially rests on the rapid deployment of innate immune defences. Should these defences fail, it is the lymphocytes-T cells and B cells-with their antigen-specific receptors that must rise to the task of providing adaptive immunity. Technological advances are now allowing immunologists to correlate data obtained in vitro with in vivo functions. A better understanding of T-cell activation in vivo could lead to more effective strategies for the treatment and prevention of infectious and autoimmmune diseases.

Original language	English
Pages (from-to)	264-271
Number of pages	8
Journal	Nature
Volume	430
Issue number	6996
DOIs	https://doi.org/10.1038/nature02762
Publication status	Published - 8 Jul 2004

Keywords

IMMUNOLOGICAL SYNAPSE FORMATION
CLASS-II TRANSPORT
TOLL-LIKE RECEPTORS
CD4 T-CELLS
DENDRITIC CELLS
ANTIGEN PRESENTATION
LYMPH-NODES
CROSS-PRESENTATION
LIPID RAFTS
TETRASPAN MICRODOMAINS

Access to Document

10.1038/nature02762

Cite this

@article{b9f542fbd4764e07a1d8a96400f08da7,

title = "Translating cell biology in vitro to immunity in vivo",

abstract = "The elimination of pathogens and pathogen-infected cells initially rests on the rapid deployment of innate immune defences. Should these defences fail, it is the lymphocytes-T cells and B cells-with their antigen-specific receptors that must rise to the task of providing adaptive immunity. Technological advances are now allowing immunologists to correlate data obtained in vitro with in vivo functions. A better understanding of T-cell activation in vivo could lead to more effective strategies for the treatment and prevention of infectious and autoimmmune diseases.",

keywords = "IMMUNOLOGICAL SYNAPSE FORMATION, CLASS-II TRANSPORT, TOLL-LIKE RECEPTORS, CD4 T-CELLS, DENDRITIC CELLS, ANTIGEN PRESENTATION, LYMPH-NODES, CROSS-PRESENTATION, LIPID RAFTS, TETRASPAN MICRODOMAINS",

author = "M Boes and HL Ploegh",

year = "2004",

month = jul,

day = "8",

doi = "10.1038/nature02762",

language = "English",

volume = "430",

pages = "264--271",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "6996",

}

TY - JOUR

T1 - Translating cell biology in vitro to immunity in vivo

AU - Boes, M

AU - Ploegh, HL

PY - 2004/7/8

Y1 - 2004/7/8

N2 - The elimination of pathogens and pathogen-infected cells initially rests on the rapid deployment of innate immune defences. Should these defences fail, it is the lymphocytes-T cells and B cells-with their antigen-specific receptors that must rise to the task of providing adaptive immunity. Technological advances are now allowing immunologists to correlate data obtained in vitro with in vivo functions. A better understanding of T-cell activation in vivo could lead to more effective strategies for the treatment and prevention of infectious and autoimmmune diseases.

AB - The elimination of pathogens and pathogen-infected cells initially rests on the rapid deployment of innate immune defences. Should these defences fail, it is the lymphocytes-T cells and B cells-with their antigen-specific receptors that must rise to the task of providing adaptive immunity. Technological advances are now allowing immunologists to correlate data obtained in vitro with in vivo functions. A better understanding of T-cell activation in vivo could lead to more effective strategies for the treatment and prevention of infectious and autoimmmune diseases.

KW - IMMUNOLOGICAL SYNAPSE FORMATION

KW - CLASS-II TRANSPORT

KW - TOLL-LIKE RECEPTORS

KW - CD4 T-CELLS

KW - DENDRITIC CELLS

KW - ANTIGEN PRESENTATION

KW - LYMPH-NODES

KW - CROSS-PRESENTATION

KW - LIPID RAFTS

KW - TETRASPAN MICRODOMAINS

U2 - 10.1038/nature02762

DO - 10.1038/nature02762

M3 - Article

C2 - 15241425

SN - 0028-0836

VL - 430

SP - 264

EP - 271

JO - Nature

JF - Nature

IS - 6996

ER -

Translating cell biology in vitro to immunity in vivo

Abstract

Keywords

Access to Document

Fingerprint

Cite this