@article{f917648b684541b088cb418f7920d221,
title = "Trans-ethnic association study of blood pressure determinants in over 750,000 individuals",
abstract = "In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.",
keywords = "Adolescent, Animals, Blood Pressure/genetics, Ethnicity/genetics, Female, Gene Expression/genetics, Genome-Wide Association Study/methods, Humans, Kidney Tubules/physiology, Male, Mice, Middle Aged, Polymorphism, Single Nucleotide/genetics, Transcriptome/genetics, Up-Regulation/genetics",
author = "Ayush Giri and Hellwege, {Jacklyn N.} and Keaton, {Jacob M.} and Jihwan Park and Chengxiang Qiu and Warren, {Helen R.} and Torstenson, {Eric S.} and Kovesdy, {Csaba P.} and Sun, {Yan V.} and Wilson, {Otis D.} and Cassianne Robinson-Cohen and Roumie, {Christianne L.} and Chung, {Cecilia P.} and Birdwell, {Kelly A.} and Damrauer, {Scott M.} and DuVall, {Scott L.} and Derek Klarin and Kelly Cho and Yu Wang and Evangelos Evangelou and Cabrera, {Claudia P.} and Wain, {Louise V.} and Rojesh Shrestha and Mautz, {Brian S.} and Akwo, {Elvis A.} and Muralidharan Sargurupremraj and St{\'e}phanie Debette and Michael Boehnke and Scott, {Laura J.} and Jian{\textquoteright}an Luan and Zhao, {Jing Hua} and Willems, {Sara M.} and S{\'e}bastien Th{\'e}riault and Nabi Shah and Christopher Oldmeadow and Peter Almgren and Ruifang Li-Gao and Niek Verweij and Boutin, {Thibaud S.} and Massimo Mangino and Ioanna Ntalla and Elena Feofanova and Praveen Surendran and Cook, {James P.} and Savita Karthikeyan and Najim Lahrouchi and Chunyu Liu and Nuno Sep{\'u}lveda and Richardson, {Tom G.} and {van der Harst}, Pim",
note = "Funding Information: P.S. received support from Pfizer Inc. N.P. has received financial support from several pharmaceutical companies which manufacture blood pressurelowering agents, for consultancy fees (Servier), research projects and staff (Servier, Pfizer) and for arranging and speaking at educational meetings (AstraZeneca, Lri Therapharma, Napi, Servier and Pfizer). He holds no stocks and shares in any such companies. M.J.C. is Chief Scientist for Genomics England, a UK Government company. B.M.P. serves on the Data Safety Monitoring Board of a clinical trial funded by Zoll LifeCor and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. D.M.K. works as a parttime clinical research consultant for Metabolon, Inc. R.A.S. is an employee and shareholder in GlaxoSmithKline plc. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung and Blood Institute (US); the National Institutes of Health (US); National Health Service (UK); National Institute for Health Research (UK); The Department of Health and Social Care (UK); the EC; or the US Department of Health and Human Services. This publication does not represent the views of the Department of Veterans Affairs or the United States government. Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2019",
month = jan,
day = "1",
doi = "10.1038/s41588-018-0303-9",
language = "English",
volume = "51",
pages = "51--+",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "1",
}