TY - JOUR
T1 - Towards predicting ECoG-BCI performance
T2 - assessing the potential of scalp-EEG *
AU - Fahimi Hnazaee, Mansoureh
AU - Verwoert, Maxime
AU - Freudenburg, Zachary V.
AU - van der Salm, Sandra M.A.
AU - Aarnoutse, Erik J.
AU - Leinders, Sacha
AU - Van Hulle, Marc M.
AU - Ramsey, Nick F.
AU - Vansteensel, Mariska J.
N1 - Funding Information:
M F is supported by Grants from PDM and FWO (G0A4118N).
Funding Information:
M M V H is supported by research grants received from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 857375, the special research fund of the KU Leuven (C24/18/098), the Belgian Fund for Scientific Research—Flanders (G0A0914N, G0A4118N, G0A4321N), the Interuniversity Attraction Poles Programme—Belgian Science Policy (IUAP P7/11), and the Hercules Foundation (AKUL 043).
Funding Information:
This work was funded by grants from the Internationalization Committee of the UMC Utrecht, Technology Foundation STW of the Dutch Research Council (12803) and the National Institute On Deafness and Other Communication Disorders of the National Institutes of Health (U01DC016686). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2022 The Author(s). Published by IOP Publishing Ltd.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Objective. Implanted brain-computer interfaces (BCIs) employ neural signals to control a computer and may offer an alternative communication channel for people with locked-in syndrome (LIS). Promising results have been obtained using signals from the sensorimotor (SM) area. However, in earlier work on home-use of an electrocorticography (ECoG)-based BCI by people with LIS, we detected differences in ECoG-BCI performance, which were related to differences in the modulation of low frequency band (LFB) power in the SM area. For future clinical implementation of ECoG-BCIs, it will be crucial to determine whether reliable performance can be predicted before electrode implantation. To assess if non-invasive scalp-electroencephalography (EEG) could serve such prediction, we here investigated if EEG can detect the characteristics observed in the LFB modulation of ECoG signals. Approach. We included three participants with LIS of the earlier study, and a control group of 20 healthy participants. All participants performed a Rest task, and a Movement task involving actual (healthy) or attempted (LIS) hand movements, while their EEG signals were recorded. Main results. Data of the Rest task was used to determine signal-to-noise ratio, which showed a similar range for LIS and healthy participants. Using data of the Movement task, we selected seven EEG electrodes that showed a consistent movement-related decrease in beta power (13-30 Hz) across healthy participants. Within the EEG recordings of this subset of electrodes of two LIS participants, we recognized the phenomena reported earlier for the LFB in their ECoG recordings. Specifically, strong movement-related beta band suppression was observed in one, but not the other, LIS participant, and movement-related alpha band (8-12 Hz) suppression was practically absent in both. Results of the third LIS participant were inconclusive due to technical issues with the EEG recordings. Significance. Together, these findings support a potential role for scalp EEG in the presurgical assessment of ECoG-BCI candidates.
AB - Objective. Implanted brain-computer interfaces (BCIs) employ neural signals to control a computer and may offer an alternative communication channel for people with locked-in syndrome (LIS). Promising results have been obtained using signals from the sensorimotor (SM) area. However, in earlier work on home-use of an electrocorticography (ECoG)-based BCI by people with LIS, we detected differences in ECoG-BCI performance, which were related to differences in the modulation of low frequency band (LFB) power in the SM area. For future clinical implementation of ECoG-BCIs, it will be crucial to determine whether reliable performance can be predicted before electrode implantation. To assess if non-invasive scalp-electroencephalography (EEG) could serve such prediction, we here investigated if EEG can detect the characteristics observed in the LFB modulation of ECoG signals. Approach. We included three participants with LIS of the earlier study, and a control group of 20 healthy participants. All participants performed a Rest task, and a Movement task involving actual (healthy) or attempted (LIS) hand movements, while their EEG signals were recorded. Main results. Data of the Rest task was used to determine signal-to-noise ratio, which showed a similar range for LIS and healthy participants. Using data of the Movement task, we selected seven EEG electrodes that showed a consistent movement-related decrease in beta power (13-30 Hz) across healthy participants. Within the EEG recordings of this subset of electrodes of two LIS participants, we recognized the phenomena reported earlier for the LFB in their ECoG recordings. Specifically, strong movement-related beta band suppression was observed in one, but not the other, LIS participant, and movement-related alpha band (8-12 Hz) suppression was practically absent in both. Results of the third LIS participant were inconclusive due to technical issues with the EEG recordings. Significance. Together, these findings support a potential role for scalp EEG in the presurgical assessment of ECoG-BCI candidates.
KW - amyotrophic lateral sclerosis
KW - brain-computer interface
KW - electrocorticography
KW - electroencephalography
KW - locked-in syndrome
KW - predict
KW - sensorimotor
UR - http://www.scopus.com/inward/record.url?scp=85137010732&partnerID=8YFLogxK
U2 - 10.1088/1741-2552/ac8764
DO - 10.1088/1741-2552/ac8764
M3 - Article
C2 - 35931055
AN - SCOPUS:85137010732
SN - 1741-2560
VL - 19
JO - Journal of Neural Engineering
JF - Journal of Neural Engineering
IS - 4
M1 - 046045
ER -