TOWARDS FURTHER REFINEMENT OF RADIOTHERAPY STRATIFICATION IN CHILDREN WITH NEPHROBLASTOMA

Raquel Davila Fajardo

doi:10.33540/1279

TOWARDS FURTHER REFINEMENT OF RADIOTHERAPY STRATIFICATION IN CHILDREN WITH NEPHROBLASTOMA

Raquel Davila Fajardo

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

Childhood renal tumours account for ~ 7% of all paediatric malignancies. Among them, Wilms tumour (WT), or nephroblastoma, is by far the most frequent. The current treatment strategies lead to ~90% overall survival in localised disease and ~ 80% in metastatic patients, yet not all patients with WT can be cured. These excellent outcomes are associated with the development of short- as well as long-term treatment-related side effects. Through the years, risk-adapted strategies have been implemented in the consecutive protocols of the existing international collaborative renal tumour groups to further improve survival while reducing treatment toxicity. The aim of this thesis was to contribute to the identification of WT patient subgroups that may benefit from the omission of radiotherapy and, in doing so, helping the decrease of the radiotherapy-related adverse effects.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	van den Heuvel-Eibrink, Marry, Primary supervisor Terhaard, CHJ, Supervisor Janssens, Geert, Co-supervisor van Grotel, Martine, Co-supervisor
Award date	10 Nov 2022
Publisher	Utrecht University
Print ISBNs	978-94-6469-115-3
DOIs	https://doi.org/10.33540/1279
Publication status	Published - 10 Nov 2022

Keywords

Childhood renal tumours
Wilms tumour
nephroblastoma
radiotherapy
brachytherapy
stratification
radiotherapy-related side effect

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10.33540/1279

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@phdthesis{24c7a2984d6a45309466da56e1d93388,

title = "TOWARDS FURTHER REFINEMENT OF RADIOTHERAPY STRATIFICATION IN CHILDREN WITH NEPHROBLASTOMA",

abstract = "Childhood renal tumours account for ~ 7% of all paediatric malignancies. Among them, Wilms tumour (WT), or nephroblastoma, is by far the most frequent. The current treatment strategies lead to ~90% overall survival in localised disease and ~ 80% in metastatic patients, yet not all patients with WT can be cured. These excellent outcomes are associated with the development of short- as well as long-term treatment-related side effects. Through the years, risk-adapted strategies have been implemented in the consecutive protocols of the existing international collaborative renal tumour groups to further improve survival while reducing treatment toxicity. The aim of this thesis was to contribute to the identification of WT patient subgroups that may benefit from the omission of radiotherapy and, in doing so, helping the decrease of the radiotherapy-related adverse effects.",

keywords = "Childhood renal tumours, Wilms tumour, nephroblastoma, radiotherapy, brachytherapy, stratification, radiotherapy-related side effect",

author = "{Davila Fajardo}, Raquel",

year = "2022",

month = nov,

day = "10",

doi = "10.33540/1279",

language = "English",

isbn = "978-94-6469-115-3",

publisher = "Utrecht University",

type = "Doctoral thesis 1 (Research UU / Graduation UU)",

school = "UMC Utrecht",

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TY - THES

T1 - TOWARDS FURTHER REFINEMENT OF RADIOTHERAPY STRATIFICATION IN CHILDREN WITH NEPHROBLASTOMA

AU - Davila Fajardo, Raquel

PY - 2022/11/10

Y1 - 2022/11/10

N2 - Childhood renal tumours account for ~ 7% of all paediatric malignancies. Among them, Wilms tumour (WT), or nephroblastoma, is by far the most frequent. The current treatment strategies lead to ~90% overall survival in localised disease and ~ 80% in metastatic patients, yet not all patients with WT can be cured. These excellent outcomes are associated with the development of short- as well as long-term treatment-related side effects. Through the years, risk-adapted strategies have been implemented in the consecutive protocols of the existing international collaborative renal tumour groups to further improve survival while reducing treatment toxicity. The aim of this thesis was to contribute to the identification of WT patient subgroups that may benefit from the omission of radiotherapy and, in doing so, helping the decrease of the radiotherapy-related adverse effects.

AB - Childhood renal tumours account for ~ 7% of all paediatric malignancies. Among them, Wilms tumour (WT), or nephroblastoma, is by far the most frequent. The current treatment strategies lead to ~90% overall survival in localised disease and ~ 80% in metastatic patients, yet not all patients with WT can be cured. These excellent outcomes are associated with the development of short- as well as long-term treatment-related side effects. Through the years, risk-adapted strategies have been implemented in the consecutive protocols of the existing international collaborative renal tumour groups to further improve survival while reducing treatment toxicity. The aim of this thesis was to contribute to the identification of WT patient subgroups that may benefit from the omission of radiotherapy and, in doing so, helping the decrease of the radiotherapy-related adverse effects.

KW - Childhood renal tumours

KW - Wilms tumour

KW - nephroblastoma

KW - radiotherapy

KW - brachytherapy

KW - stratification

KW - radiotherapy-related side effect

U2 - 10.33540/1279

DO - 10.33540/1279

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-94-6469-115-3

PB - Utrecht University

ER -

TOWARDS FURTHER REFINEMENT OF RADIOTHERAPY STRATIFICATION IN CHILDREN WITH NEPHROBLASTOMA

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Keywords

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