Towards functional spin-echo BOLD line-scanning in humans at 7T

Luisa Raimondo*, Jurjen Heij, Tomas Knapen, Serge O. Dumoulin, Wietske van der Zwaag, Jeroen C.W. Siero

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Downloads (Pure)


Objective: Neurons cluster into sub-millimeter spatial structures and neural activity occurs at millisecond resolutions; hence, ultimately, high spatial and high temporal resolutions are required for functional MRI. In this work, we implemented a spin-echo line-scanning (SELINE) sequence to use in high spatial and temporal resolution fMRI. Materials and methods: A line is formed by simply rotating the spin-echo refocusing gradient to a plane perpendicular to the excited slice and by removing the phase-encoding gradient. This technique promises a combination of high spatial and temporal resolution (250 μm, 500 ms) and microvascular specificity of functional responses. We compared SELINE data to a corresponding gradient-echo version (GELINE). Results: We demonstrate that SELINE showed much-improved line selection (i.e. a sharper line profile) compared to GELINE, albeit at the cost of a significant drop in functional sensitivity. Discussion: This low functional sensitivity needs to be addressed before SELINE can be applied for neuroscientific purposes.

Original languageEnglish
Pages (from-to)317-327
Number of pages11
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Issue number2
Publication statusPublished - Apr 2023


  • 7T
  • fMRI
  • High spatiotemporal resolution
  • Line-scanning
  • Spin-echo


Dive into the research topics of 'Towards functional spin-echo BOLD line-scanning in humans at 7T'. Together they form a unique fingerprint.

Cite this