Towards functional spin-echo BOLD line-scanning in humans at 7T

Luisa Raimondo; Jurjen Heij; Tomas Knapen; Serge O. Dumoulin; Wietske van der Zwaag; Jeroen C.W. Siero

doi:10.1007/s10334-022-01059-7

Towards functional spin-echo BOLD line-scanning in humans at 7T

Luisa Raimondo^*, Jurjen Heij, Tomas Knapen, Serge O. Dumoulin, Wietske van der Zwaag, Jeroen C.W. Siero

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: Neurons cluster into sub-millimeter spatial structures and neural activity occurs at millisecond resolutions; hence, ultimately, high spatial and high temporal resolutions are required for functional MRI. In this work, we implemented a spin-echo line-scanning (SELINE) sequence to use in high spatial and temporal resolution fMRI. Materials and methods: A line is formed by simply rotating the spin-echo refocusing gradient to a plane perpendicular to the excited slice and by removing the phase-encoding gradient. This technique promises a combination of high spatial and temporal resolution (250 μm, 500 ms) and microvascular specificity of functional responses. We compared SELINE data to a corresponding gradient-echo version (GELINE). Results: We demonstrate that SELINE showed much-improved line selection (i.e. a sharper line profile) compared to GELINE, albeit at the cost of a significant drop in functional sensitivity. Discussion: This low functional sensitivity needs to be addressed before SELINE can be applied for neuroscientific purposes.

Original language	English
Pages (from-to)	317-327
Number of pages	11
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume	36
Issue number	2
DOIs	https://doi.org/10.1007/s10334-022-01059-7
Publication status	Published - Apr 2023

Keywords

7T
fMRI
High spatiotemporal resolution
Line-scanning
Spin-echo

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title = "Towards functional spin-echo BOLD line-scanning in humans at 7T",

abstract = "Objective: Neurons cluster into sub-millimeter spatial structures and neural activity occurs at millisecond resolutions; hence, ultimately, high spatial and high temporal resolutions are required for functional MRI. In this work, we implemented a spin-echo line-scanning (SELINE) sequence to use in high spatial and temporal resolution fMRI. Materials and methods: A line is formed by simply rotating the spin-echo refocusing gradient to a plane perpendicular to the excited slice and by removing the phase-encoding gradient. This technique promises a combination of high spatial and temporal resolution (250 μm, 500 ms) and microvascular specificity of functional responses. We compared SELINE data to a corresponding gradient-echo version (GELINE). Results: We demonstrate that SELINE showed much-improved line selection (i.e. a sharper line profile) compared to GELINE, albeit at the cost of a significant drop in functional sensitivity. Discussion: This low functional sensitivity needs to be addressed before SELINE can be applied for neuroscientific purposes.",

keywords = "7T, fMRI, High spatiotemporal resolution, Line-scanning, Spin-echo",

author = "Luisa Raimondo and Jurjen Heij and Tomas Knapen and Dumoulin, {Serge O.} and {van der Zwaag}, Wietske and Siero, {Jeroen C.W.}",

note = "Funding Information: This study was supported by the Royal Netherlands Academy of Sciences Research Fund 2018 (KNAW BDO/3489) to J.C.W.S., T.K., W.v.d.Z., S.O.D., the Visiting Professors Programme 2017 (KNAW WF/RB/3781) granted to J.C.W.S, S.O.D and a Netherlands Organization for Scientific Research (NWO) Vidi Grant (TTW VI.Vidi.198.016 to W.Z.) to W.v.d.Z. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = apr,

doi = "10.1007/s10334-022-01059-7",

language = "English",

volume = "36",

pages = "317--327",

journal = "Magnetic Resonance Materials in Physics, Biology and Medicine",

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AU - Raimondo, Luisa

AU - Heij, Jurjen

AU - Knapen, Tomas

AU - Dumoulin, Serge O.

AU - van der Zwaag, Wietske

AU - Siero, Jeroen C.W.

N1 - Funding Information: This study was supported by the Royal Netherlands Academy of Sciences Research Fund 2018 (KNAW BDO/3489) to J.C.W.S., T.K., W.v.d.Z., S.O.D., the Visiting Professors Programme 2017 (KNAW WF/RB/3781) granted to J.C.W.S, S.O.D and a Netherlands Organization for Scientific Research (NWO) Vidi Grant (TTW VI.Vidi.198.016 to W.Z.) to W.v.d.Z. Publisher Copyright: © 2023, The Author(s).

PY - 2023/4

Y1 - 2023/4

N2 - Objective: Neurons cluster into sub-millimeter spatial structures and neural activity occurs at millisecond resolutions; hence, ultimately, high spatial and high temporal resolutions are required for functional MRI. In this work, we implemented a spin-echo line-scanning (SELINE) sequence to use in high spatial and temporal resolution fMRI. Materials and methods: A line is formed by simply rotating the spin-echo refocusing gradient to a plane perpendicular to the excited slice and by removing the phase-encoding gradient. This technique promises a combination of high spatial and temporal resolution (250 μm, 500 ms) and microvascular specificity of functional responses. We compared SELINE data to a corresponding gradient-echo version (GELINE). Results: We demonstrate that SELINE showed much-improved line selection (i.e. a sharper line profile) compared to GELINE, albeit at the cost of a significant drop in functional sensitivity. Discussion: This low functional sensitivity needs to be addressed before SELINE can be applied for neuroscientific purposes.

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Towards functional spin-echo BOLD line-scanning in humans at 7T

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