Toward Antibacterial Coatings for Personalized Implants

F. Jahanmard; F. M. Dijkmans; A. Majed; H. C. Vogely; B. C.H. Van Der Wal; D. A.C. Stapels; S. M. Ahmadi; T. Vermonden; S. Amin Yavari

doi:10.1021/acsbiomaterials.0c00683

Toward Antibacterial Coatings for Personalized Implants

F. Jahanmard, F. M. Dijkmans, A. Majed, H. C. Vogely, B. C.H. Van Der Wal, D. A.C. Stapels, S. M. Ahmadi, T. Vermonden, S. Amin Yavari^*

^*Corresponding author for this work

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Abstract

The complex reconstructive surgeries for which patient-specific orthopedic, maxillofacial, or dental implants are used often necessitate wounds that are open for a considerable amount of time. Unsurprisingly, this allows bacteria to establish implant-associated infection, despite the scrupulous sterilization efforts made during surgery. Here, we developed a prophylactic bactericidal coating via electrophoretic deposition technology for two 3D-printed porous titanium implant designs. The surface characteristics, antibiotic release behavior, antibacterial properties, and impact on osteoblast cell proliferation of the optimized coatings were investigated. The results unequivocally confirmed the biofunctionality of the implants in vitro. This study reveals a new avenue for future antibacterial patient-specific implants.

Original language	English
Pages (from-to)	5486-5492
Number of pages	7
Journal	ACS Biomaterials Science and Engineering
Volume	6
Issue number	10
DOIs	https://doi.org/10.1021/acsbiomaterials.0c00683
Publication status	Published - 12 Oct 2020

Keywords

antibacterial coating
metal 3D printing
personalized implants

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title = "Toward Antibacterial Coatings for Personalized Implants",

abstract = "The complex reconstructive surgeries for which patient-specific orthopedic, maxillofacial, or dental implants are used often necessitate wounds that are open for a considerable amount of time. Unsurprisingly, this allows bacteria to establish implant-associated infection, despite the scrupulous sterilization efforts made during surgery. Here, we developed a prophylactic bactericidal coating via electrophoretic deposition technology for two 3D-printed porous titanium implant designs. The surface characteristics, antibiotic release behavior, antibacterial properties, and impact on osteoblast cell proliferation of the optimized coatings were investigated. The results unequivocally confirmed the biofunctionality of the implants in vitro. This study reveals a new avenue for future antibacterial patient-specific implants. ",

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doi = "10.1021/acsbiomaterials.0c00683",

language = "English",

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T1 - Toward Antibacterial Coatings for Personalized Implants

AU - Jahanmard, F.

AU - Dijkmans, F. M.

AU - Majed, A.

AU - Vogely, H. C.

AU - Van Der Wal, B. C.H.

AU - Stapels, D. A.C.

AU - Ahmadi, S. M.

AU - Vermonden, T.

AU - Amin Yavari, S.

PY - 2020/10/12

Y1 - 2020/10/12

N2 - The complex reconstructive surgeries for which patient-specific orthopedic, maxillofacial, or dental implants are used often necessitate wounds that are open for a considerable amount of time. Unsurprisingly, this allows bacteria to establish implant-associated infection, despite the scrupulous sterilization efforts made during surgery. Here, we developed a prophylactic bactericidal coating via electrophoretic deposition technology for two 3D-printed porous titanium implant designs. The surface characteristics, antibiotic release behavior, antibacterial properties, and impact on osteoblast cell proliferation of the optimized coatings were investigated. The results unequivocally confirmed the biofunctionality of the implants in vitro. This study reveals a new avenue for future antibacterial patient-specific implants.

AB - The complex reconstructive surgeries for which patient-specific orthopedic, maxillofacial, or dental implants are used often necessitate wounds that are open for a considerable amount of time. Unsurprisingly, this allows bacteria to establish implant-associated infection, despite the scrupulous sterilization efforts made during surgery. Here, we developed a prophylactic bactericidal coating via electrophoretic deposition technology for two 3D-printed porous titanium implant designs. The surface characteristics, antibiotic release behavior, antibacterial properties, and impact on osteoblast cell proliferation of the optimized coatings were investigated. The results unequivocally confirmed the biofunctionality of the implants in vitro. This study reveals a new avenue for future antibacterial patient-specific implants.

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Toward Antibacterial Coatings for Personalized Implants

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